School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.
Carbohydr Polym. 2013 Jan 30;92(1):84-9. doi: 10.1016/j.carbpol.2012.09.066. Epub 2012 Oct 2.
Fucoidan extracted from Ecklonia cava had strong anti-inflammatory activities. However, the direct effects of fucoidan of E. cava on anti-inflammatory activities in vivo model remained to be determined. Therefore, the present study was designed to assess in vivo anti-inflammatory effect of fucoidan extracted from E. cava (ECF) using tail-cutting-induced and lipopolysaccharide (LPS)-stimulated zebrafish model. Treating zebrafish model with tail-cutting and LPS-treatment significantly increased the ROS and NO level. However, ECF inhibited this tail-cutting-induced and LPS-stimulated ROS and NO generation. These results show that ECF alleviated inflammation by inhibiting the ROS and NO generation induced by tail-cutting and LPS-treatment. In addition, ECF has a protective effect against the toxicity induced by LPS exposure in zebrafish embryos. This outcome could explain the potential anti-inflammatory activity of ECF, which might have a beneficial effect during the treatment of inflammatory diseases.
裙带菜中提取的褐藻糖胶具有很强的抗炎活性。然而，裙带菜褐藻糖胶对体内抗炎模型的直接作用仍有待确定。因此，本研究旨在利用剪尾诱导和脂多糖（LPS）刺激的斑马鱼模型来评估裙带菜中提取的褐藻糖胶（ECF）的体内抗炎作用。用剪尾和 LPS 处理斑马鱼模型会显著增加 ROS 和 NO 水平。然而，ECF 抑制了这种由剪尾和 LPS 刺激引起的 ROS 和 NO 的产生。这些结果表明，ECF 通过抑制由剪尾和 LPS 处理诱导的 ROS 和 NO 的产生来缓解炎症。此外，ECF 对斑马鱼胚胎暴露于 LPS 引起的毒性具有保护作用。这一结果可以解释 ECF 的潜在抗炎活性，这可能对炎症性疾病的治疗有有益的影响。
