Ding Yin, Hu Yong, Zhang Leyang, Chen Ying, Jiang Xiqun
Lab of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
Biomacromolecules. 2006 Jun;7(6):1766-72. doi: 10.1021/bm060085h.
Magnetic hybrid hollow spheres of about 200 nm were prepared by a core-template-free route, that is, adding Fe3O4 nanoparticles stabilized by poly(vinyl alcohol) (PVA) to an aqueous solution of polymer-monomer pairs composed of a cationic polymer, chitosan (CS), and an anionic monomer, acrylic acid (AA), followed by polymerization of acrylic acid and selective cross-linking of chitosan at the end of polymerization. The obtained hybrid spheres were characterized by dynamic light scattering (DLS) in aqueous solution and observed by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and atomic force microscopy (AFM) in the solid state. Fourier transform infrared spectroscopy (FTIR) and X-ray and electron diffractions revealed that the Fe3O4 nanoparticles were incorporated into the shells of chitosan-poly(acrylic acid) (CS-AA) hollow spheres. Magnetization studies and Mössbauer spectroscopy suggested that the chains (or islands) of iron oxide nanoparticles were most likely formed in the walls of the hollow spheres. The phantom test of magnetic resonance imaging showed that the synthesized hybrid hollow spheres had a significant magnetic resonance signal enhancement in T2-weighted image.
通过无核模板法制备了直径约200 nm的磁性杂化空心球，即把由聚乙烯醇（PVA）稳定的Fe3O4纳米颗粒加入到由阳离子聚合物壳聚糖（CS）和阴离子单体丙烯酸（AA）组成的聚合物 - 单体对的水溶液中，随后进行丙烯酸的聚合以及聚合结束时壳聚糖的选择性交联。所得杂化球在水溶液中通过动态光散射（DLS）进行表征，并通过透射电子显微镜（TEM）、扫描电子显微镜（SEM）和原子力显微镜（AFM）在固态下进行观察。傅里叶变换红外光谱（FTIR）以及X射线和电子衍射表明，Fe3O4纳米颗粒被并入壳聚糖 - 聚丙烯酸（CS - AA）空心球的壳层中。磁化研究和穆斯堡尔光谱表明，空心球壁中很可能形成了氧化铁纳米颗粒链（或岛）。磁共振成像的体模测试表明，合成的杂化空心球在T2加权图像中具有显著的磁共振信号增强。
