Division of Toxicology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Thiruvananthapuram 695012, Kerala, India.
Carbohydr Polym. 2013 Jan 30;92(1):726-32. doi: 10.1016/j.carbpol.2012.09.098. Epub 2012 Oct 8.
Iron oxide nanoparticles are one of the most important genres of nanoparticles with promise. Dextran, a stable biocompatible coating agent was employed in the synthesis of iron oxide nanoparticles in the presence of urea. The morphology of nanoparticles was confirmed by dynamic light scattering and transmission electron microscopy. These particles were also assessed for cytotoxicity, cellular uptake and cell adhesion in vitro using murine fibroblast cell line. The synthesized nanoparticles were superparamagnetic, possessed spherical shape with narrow size distribution and were found to be biocompatible and non-toxic. This study serves as a background for using DIONPs in further in vitro and in vivo studies with a long term goal of using it in biological applications.
氧化铁纳米颗粒是最有前途的纳米颗粒之一。在尿素存在的情况下，葡聚糖作为一种稳定的生物相容性涂层剂被用于合成氧化铁纳米颗粒。通过动态光散射和透射电子显微镜证实了纳米颗粒的形态。还使用鼠成纤维细胞系在体外评估了这些颗粒的细胞毒性、细胞摄取和细胞黏附能力。合成的纳米颗粒具有超顺磁性，呈球形，粒径分布较窄，且具有良好的生物相容性和低毒性。本研究为进一步在体外和体内研究中使用 DIONP 奠定了基础，长期目标是将其应用于生物领域。
