Shaterabadi Zhila, Nabiyouni Gholamreza, Soleymani Meysam
Department of Physics, Arak University, Arak 38156-88349, Iran.
Department of Physics, Arak University, Arak 38156-88349, Iran.
Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:947-956. doi: 10.1016/j.msec.2017.02.143. Epub 2017 Feb 28.
Biocompatible ferrofluids based on dextran coated iron oxide nanoparticles were fabricated by conventional co-precipitation method. The experimental results show that the presence of dextran in reaction medium not only causes to the appearance of superparamagnetic behavior but also results in significant suppression in saturation magnetization of dextran coated samples. These results can be attributed to size reduction originated from the role of dextran as a surfactant. Moreover, weight ratio of dextran to magnetic nanoparticles has a remarkable influence on size and magnetic properties of nanoparticles, so that the sample prepared with a higher weight ratio of dextran to nanoparticles has the smaller size and saturation magnetization compare with the other samples. In addition, the ferrofluids containing such nanoparticles have an excellent stability at physiological pH for several months. Furthermore, the biocompatibility studies reveal that surface modification of nanoparticles by dextran dramatically decreases the cytotoxicity of bare nanoparticles and consequently improves their potential application for diagnostic and therapeutic purposes.
基于葡聚糖包覆的氧化铁纳米颗粒的生物相容性铁磁流体通过传统共沉淀法制备。实验结果表明，反应介质中葡聚糖的存在不仅导致超顺磁行为的出现，还导致葡聚糖包覆样品的饱和磁化强度显著降低。这些结果可归因于葡聚糖作为表面活性剂作用导致的粒径减小。此外，葡聚糖与磁性纳米颗粒的重量比对纳米颗粒的尺寸和磁性有显著影响，因此与其他样品相比，以较高葡聚糖与纳米颗粒重量比制备的样品具有更小的尺寸和饱和磁化强度。此外，含有此类纳米颗粒的铁磁流体在生理pH值下具有数月的优异稳定性。此外，生物相容性研究表明，葡聚糖对纳米颗粒的表面改性显著降低了裸纳米颗粒的细胞毒性，从而提高了它们在诊断和治疗方面的潜在应用价值。
