Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan; Division of Allergy, Immunology, Rheumatology Disease, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
Division of Allergy, Immunology, Rheumatology Disease, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
J Microbiol Immunol Infect. 2015 Jun;48(3):340-4. doi: 10.1016/j.jmii.2012.09.002. Epub 2012 Dec 3.
Pachydermodactyly (PDD), Greek for thick-skin-finger, is an infrequently recognized benign disorder characterized by painless fusiform swelling of the soft tissues around the proximal interphalangeal joints of the hands. Histopathologic features include increased dermal accumulation of collagen fibers. Young males are predominantly affected. PDD is quite rare with approximately 90 cumulative cases reported worldwide. We report three new cases of PDD in Taiwan, including two female patients. Except for patient 1 having the habit of cracking the knuckles, and patient 2 having a history of patent ductus ateriosus post catheterization, the histories of all three patients were unremarkable. X-ray of bilateral hands revealed no abnormal finding except for soft tissue swelling around proximal interphalangeal joints. Laboratory examinations all showed negative results. No local or systemic treatment was given to these patients to treat PDD, with the exception of non-steroidal anti-inflammatory drugs prescribed to one patient for a short period. Skin care with local irritation avoidance was explained to all three patients. The long-term outcome of PDD was benign.
厚皮指（PDD），在希腊语中意为“厚皮手指”，是一种罕见的良性疾病，其特征是手指近节指间关节周围的软组织出现无痛性梭形肿胀。组织病理学特征包括真皮胶原纤维的堆积增加。主要影响年轻男性。全世界大约有 90 例累积病例报告，因此 PDD 非常罕见。我们在台湾报告了三例新的 PDD 病例，包括两名女性患者。除了 1 号患者有掰指关节的习惯，2 号患者有动脉导管未闭经导管治疗后病史外，这 3 例患者的病史均无异常。双手 X 射线除了显示近节指间关节周围软组织肿胀外，没有其他异常发现。实验室检查均呈阴性结果。除了给一名患者短期开了非甾体抗炎药外，未对这些患者进行局部或全身治疗。向所有患者解释了皮肤护理和避免局部刺激。PDD 的长期预后良好。
