Bardazzi F, Neri I, Raone B, Patrizi A
Dipartimento di Medicina Clinica specialistica e Sperimentale, Università degli Studi di Bologna, Italie.
Ann Dermatol Venereol. 1998 Apr;125(4):247-50.
Pachydermodactyly is a superficial benign digital fibromatosis usually involving the proximal portions of the fingers. It is clinically characterized by an asymptomatic, bulbous, soft-tissue swelling around proximal phalanges and interphalangeal joints. We report here seven new cases of pachydermodactyly.
Seven patients (4 F, 3 M) ranging in age from 14 to 63 years were studied. Two of them were affected by tuberous sclerosis; two other patients were sisters, one of whom was affected by the transgrediens form of pachydermodactyly. The personal history of two male patients revealed the compulsive habit of interlacing the fingers. Finally a 23-year-old patient was affected by the localized pachydermodactyly. In all the patients roentgenogram and echography of the affected fingers as well as histological and ultrastructural of a cutaneous biopsy examination were carried out. The results of the tests confirmed the diagnosis of pachydermodactyly.
Our data suggest that pachydermodactyly is underestimated rather than rare and more frequent in females than in males as until now reported in the literature. We suggest classifying pachydermodactyly into five types: classic pachydermodactyly frequently associated with mechanical trauma, monopachydermodactyly or localized pachydermodactyly, transgrediens pachydermodactyly in which the cutaneous thickness extends to the metacarpophalangeal areas, familial pachydermodactyly which may by transgrediens and pachydermodactyly associated with tuberous sclerosis.
厚皮性多指（趾）纤维瘤病是一种浅表性良性指（趾）纤维瘤病，通常累及手指近端。其临床特征为近端指骨和指间关节周围无症状的球根状软组织肿胀。我们在此报告7例新的厚皮性多指（趾）纤维瘤病病例。
研究了7例年龄在14至63岁之间的患者（4例女性，3例男性）。其中2例患有结节性硬化症；另外2例患者是姐妹，其中1例患有厚皮性多指（趾）纤维瘤病的进行性类型。2例男性患者的个人史显示有交叉手指的强迫习惯。最后，1例23岁患者患有局限性厚皮性多指（趾）纤维瘤病。对所有患者受累手指进行了X线检查和超声检查，并对皮肤活检进行了组织学和超微结构检查。检查结果证实了厚皮性多指（趾）纤维瘤病的诊断。
我们的数据表明，厚皮性多指（趾）纤维瘤病被低估而非罕见，且女性比男性更常见，正如迄今为止文献中所报道的那样。我们建议将厚皮性多指（趾）纤维瘤病分为五种类型：常与机械性创伤相关的经典厚皮性多指（趾）纤维瘤病、单发性厚皮性多指（趾）纤维瘤病或局限性厚皮性多指（趾）纤维瘤病、皮肤厚度延伸至掌指区域的进行性厚皮性多指（趾）纤维瘤病、可能为进行性的家族性厚皮性多指（趾）纤维瘤病以及与结节性硬化症相关的厚皮性多指（趾）纤维瘤病。
