Keratoconus Unit, Vissum Corporation, Alicante, Spain.
Am J Ophthalmol. 2013 Mar;155(3):575-584.e1. doi: 10.1016/j.ajo.2012.08.020. Epub 2012 Dec 4.
To analyze the outcomes of intracorneal ring segment (ICRS) implantation for the treatment of keratoconus based on preoperative visual impairment.
Multicenter, retrospective, nonrandomized study.
A total of 611 eyes of 361 keratoconic patients were evaluated. Subjects were classified according to their preoperative corrected distance visual acuity (CDVA) into 5 different groups: grade I, CDVA of 0.90 or better; grade II, CDVA equal to or better than 0.60 and worse than 0.90; grade III, CDVA equal to or better than 0.40 and worse than 0.60; grade IV, CDVA equal to or better than 0.20 and worse than 0.40; and grade plus, CDVA worse than 0.20. Success and failure indices were defined based on visual, refractive, corneal topographic, and aberrometric data and evaluated in each group 6 months after ICRS implantation.
Significant improvement after the procedure was observed regarding uncorrected distance visual acuity in all grades (P < .05). CDVA significantly decreased in grade I (P < .01) but significantly increased in all other grades (P < .05). A total of 37.9% of patients with preoperative CDVA 0.6 or better gained 1 or more lines of CDVA, whereas 82.8% of patients with preoperative CDVA 0.4 or worse gained 1 or more lines of CDVA (P < .01). Spherical equivalent and keratometry readings showed a significant reduction in all grades (P ≤ .02). Corneal higher-order aberrations did not change after the procedure (P ≥ .05).
Based on preoperative visual impairment, ICRS implantation provides significantly better results in patients with a severe form of the disease. A notable loss of CDVA lines can be expected in patients with a milder form of keratoconus.
根据术前视力损害情况,分析角膜内环段(ICRS)植入治疗圆锥角膜的效果。
多中心、回顾性、非随机研究。
共评估了 361 例圆锥角膜患者的 611 只眼。根据术前矫正远视力(CDVA)将受试者分为 5 个不同组别:I 级,CDVA 为 0.90 或更好;II 级,CDVA 等于或好于 0.60 但差于 0.90;III 级,CDVA 等于或好于 0.40 但差于 0.60;IV 级,CDVA 等于或好于 0.20 但差于 0.40;加级,CDVA 差于 0.20。根据视力、屈光、角膜地形图和像差数据,在 ICRS 植入术后 6 个月定义成功和失败指数,并在每个组中进行评估。
所有级别术后未矫正远视力均有显著改善(P<.05)。I 级 CDVA 显著下降(P<.01),但所有其他级别均显著增加(P<.05)。术前 CDVA 为 0.6 或更好的患者中有 37.9%的患者获得了 1 行或更多行的 CDVA,而术前 CDVA 为 0.4 或更差的患者中有 82.8%的患者获得了 1 行或更多行的 CDVA(P<.01)。所有级别球镜和角膜曲率读数均显著降低(P≤.02)。术后角膜高阶像差无变化(P≥.05)。
根据术前视力损害情况,ICRS 植入在疾病严重程度较高的患者中提供了显著更好的结果。在疾病较轻的患者中,CDVA 线的显著损失是可以预期的。