Lipid Research Group, Heart Research Institute, Sydney, New South Wales, Australia.
Ann Epidemiol. 2013 Feb;23(2):80-6. doi: 10.1016/j.annepidem.2012.11.008. Epub 2012 Dec 5.
Arthritis is associated with cardiovascular diseases (CVDs). However, there are limited epidemiologic studies on arthritis in a national survey study. We therefore investigated the prevalence of self-reported arthritis and its association with CVDs.
Data from 15,888 subjects aged 40 years or older in the United States National Health and Nutrition Examination Survey 1999 through 2008 were analyzed. CVD was defined as a self-reported history of heart attack, congestive heart failure, coronary heart disease, angina, or stroke.
The overall prevalence of self-reported arthritis in subjects aged 40 years or older increased from 33.5% in 1999 through 2000 to 37.0% in 2007 through 2008 (P for trend = 0.017). Among subjects with arthritis in 1999 through 2008, 35.3% had osteoarthritis (OA), 17.9% had rheumatoid arthritis (RA), and 10.2% had other types of arthritis, but 36.6% were unaware of their type of arthritis. Compared with subjects without OA, subjects with OA had higher odds for CVDs (odds ratio [OR], 1.53; P < .001), especially angina (OR, 2.18: P < .001). Compared with subjects without RA, subjects with RA had higher odds for CVDs (adjusted OR, 2.39; P < .001), especially congestive heart failure (OR, 3.59; P < .001).
Both RA and OA are strongly associated with CVDs in the general population. Further studies are needed to investigate their causal relationship.
关节炎与心血管疾病（CVD）相关。然而，在全国性调查研究中，关于关节炎的流行病学研究有限。因此，我们调查了自我报告的关节炎的患病率及其与 CVD 的关系。
分析了美国国家健康和营养检查调查 1999 年至 2008 年期间年龄在 40 岁及以上的 15888 名受试者的数据。CVD 的定义为自我报告的心脏病发作、充血性心力衰竭、冠心病、心绞痛或中风病史。
在年龄在 40 岁及以上的受试者中，自我报告的关节炎总体患病率从 1999 年至 2000 年的 33.5%增加到 2007 年至 2008 年的 37.0%（趋势 P=0.017）。在 1999 年至 2008 年患有关节炎的受试者中，35.3%为骨关节炎（OA），17.9%为类风湿关节炎（RA），10.2%为其他类型的关节炎，但 36.6%的人不知道自己的关节炎类型。与没有 OA 的受试者相比，OA 受试者发生 CVD 的几率更高（优势比[OR]，1.53；P<0.001），尤其是心绞痛（OR，2.18：P<0.001）。与没有 RA 的受试者相比，RA 受试者发生 CVD 的几率更高（调整后的 OR，2.39；P<0.001），尤其是充血性心力衰竭（OR，3.59；P<0.001）。
RA 和 OA 在普通人群中均与 CVD 密切相关。需要进一步研究以探讨它们之间的因果关系。
