Singh Gurkirpal, Miller Jeffrey D, Lee Fleur H, Pettitt Dan, Russell Mason W
ARAIS-PMS Program, Stanford University School of Medicine, Palo Alto, California, USA.
Am J Manag Care. 2002 Oct;8(15 Suppl):S383-91.
To estimate the prevalence of traditional risk factors for cardiovascular disease (CVD) among US adults with osteoarthritis (OA).
Using survey data from the Third National Health and Nutrition Examination Survey, we estimated the prevalence of selected CVD risk factors among a US OA and nonarthritic adult population. In additional analyses, we stratified the sample by gender and age (35-44, 45-64, and 65+ years) to further understand the CVD risk profile in an arthritic population and nonarthritic population. Relevant data on each survey participant's demographics, arthritis status, CVD risk factors, and sampling weights were obtained from the survey database.
Of the 115.9 million US adults aged > or = 35 years, 24.3 million (21%) have OA. Hypertension is prevalent in approximately 40% of OA patients; 20% of the patients smoke and 11% have diabetes. Prevalence of high total cholesterol is estimated to be 32%, while prevalence of low high-density lipoprotein cholesterol is estimated at 13%. Approximately 37% of OA patients are estimated to have renal impairment, but less than 1% suffer from renal failure.
National survey data suggest that, on average, US adults with OA have a high prevalence of cardiovascular risk factors. These findings highlight the need to consider patients' comorbidites when selecting the appropriate treatment options.
评估美国骨关节炎（OA）成年患者中心血管疾病（CVD）传统危险因素的患病率。
利用第三次全国健康与营养检查调查的调查数据，我们估算了美国OA成年患者和非关节炎成年人群中特定CVD危险因素的患病率。在进一步分析中，我们按性别和年龄（35 - 44岁、45 - 64岁和65岁及以上）对样本进行分层，以进一步了解关节炎人群和非关节炎人群的CVD风险状况。从调查数据库中获取了每位调查参与者的人口统计学、关节炎状况、CVD危险因素及抽样权重的相关数据。
在1.159亿年龄≥35岁的美国成年人中，2430万（21%）患有OA。高血压在约40%的OA患者中普遍存在；20%的患者吸烟，11%患有糖尿病。总胆固醇高的患病率估计为32%，而高密度脂蛋白胆固醇低的患病率估计为13%。估计约37%的OA患者有肾功能损害，但不到1%的患者患有肾衰竭。
全国性调查数据表明，美国OA成年患者平均心血管危险因素患病率较高。这些发现凸显了在选择合适治疗方案时考虑患者合并症的必要性。
