National Institute of Cholera and Enteric Diseases, Kolkata, India.
Infect Genet Evol. 2013 Mar;14:15-21. doi: 10.1016/j.meegid.2012.11.010. Epub 2012 Dec 3.
In a community based case-control study in Kolkata, India, in 2009, two human rotaviruses with uncommon genotypes G6P[14] and G11P[25] were identified, having bovine and porcine characteristics respectively. Strain N-1/2009 with G6P[14] and strain N-38/2009 with G11P[25] genotypes, were isolated from a 13months aged boy who was asymptomatic and a 10months old girl with severe diarrhea respectively. The remaining 9 gene segments of these two strains were analyzed to find the exact origin of these unusual rotaviruses, and the origin of these two strains from bovine/porcine rotaviruses was apparent. This study identifies zoonotic transmission and single and multiple reassortment events as mechanisms driving the diversity of human rotaviruses. This study indicates interspecies transmission between human and animal rotaviruses causes single or multiple reassortment and thus contribute to the genetic diversity of rotavirus.
在 2009 年印度加尔各答进行的一项基于社区的病例对照研究中，发现了两种具有罕见基因型 G6P[14]和 G11P[25]的人类轮状病毒，它们分别具有牛和猪的特征。具有 G6P[14]基因型的 N-1/2009 株和具有 G11P[25]基因型的 N-38/2009 株分别从一名无症状的 13 个月大男孩和一名患有严重腹泻的 10 个月大女孩中分离出来。对这两种菌株的其余 9 个基因片段进行了分析，以确定这两种不寻常轮状病毒的确切来源，结果表明这两种菌株来自牛/猪轮状病毒。本研究确定了人畜共患传播以及单一和多次重配事件是导致人类轮状病毒多样性的机制。本研究表明，人类和动物轮状病毒之间的种间传播会导致单一或多次重配，从而导致轮状病毒的遗传多样性。
