Department of Medicine and Experimental Oncology, Section of Clinical Pathology, University of Turin, Turin, Italy.
Autoimmun Rev. 2013 Jun;12(8):814-20. doi: 10.1016/j.autrev.2012.11.005. Epub 2012 Dec 6.
Miniaturization of analytical procedures has a significant impact on diagnostic testing since it provides several advantages such as: reduced sample and reagent consumption, shorter analysis time and less sample handling. Lab-on-a-chip (LoC), usually silicon, glass, or silicon-glass, or polymer disposable cartridges, which are produced using techniques inherited from the microelectronics industry, could perform and integrate the operations needed to carry out biochemical analysis through the mechanical realization of a dedicated instrument. Analytical devices based on miniaturized platforms like LoC may provide an important contribution to the diagnosis of high prevalence and rare diseases. In this paper we review some of the uses of Lab-on-a-chip in the clinical diagnostics of immune-mediated diseases and we provide an overview of how specific applications of these technologies could improve and simplify several complex diagnostic procedures.
分析程序的小型化对诊断测试有重大影响，因为它提供了多个优势，如减少样品和试剂消耗、更短的分析时间和更少的样品处理。芯片实验室（Lab-on-a-chip，LoC），通常由硅、玻璃或硅-玻璃或聚合物制成的一次性试剂盒组成，这些试剂盒是使用微电子行业继承的技术制造的，可以通过专用仪器的机械实现来执行和整合进行生化分析所需的操作。基于像 LoC 这样的小型化平台的分析设备可能对高患病率和罕见病的诊断做出重要贡献。在本文中，我们回顾了 LoC 在免疫介导性疾病的临床诊断中的一些应用，并概述了这些技术的特定应用如何改进和简化几个复杂的诊断程序。
