Institute of Food, Nutrition and Human Health, Massey University, Private Bag, 102 904 North Shore Mail Centre, Auckland, New Zealand.
J Steroid Biochem Mol Biol. 2013 Jul;136:330-2. doi: 10.1016/j.jsbmb.2012.11.015. Epub 2012 Dec 7.
The identification of the vitamin D receptor (VDR) in skeletal muscle tissue and research in muscle strength and development in VDR-null mice confirms a role for vitamin D in muscle function. The relationship between muscle strength and vitamin D status has been explored to some degree in older populations with regard to fall prevention, but there has been very little research in younger adults. This cross-sectional study considered the predictors of muscle strength in 137 young women (19-29 years) living in New Zealand. The following measurements were taken in the latter months of winter: plasma 25OHD, dominant (HGD) and non-dominant hand-grip (HGND) strength (hand-grip dynamometer), counter measure jump, and recreational physical activity (RPA) assessed from a recent physical activity questionnaire (RPAQ). Dietary intake was measured with a four-day food diary, and body composition using air displacement plethysmography. This was a relatively inactive group of women; total RPA ranged from 0 to 3.93h per week, mean (SD) 0.86(0.74) h, approximately 50% comprised outdoor activities. Mean 25OHD was 54(28)nmol/l, HGD and HGND were significantly different (t=6.049, p<0.001) at 27.3(5.8) and 25.6(5.7)kg respectively. Total RPA and 25OHD were entered into a linear regression model with handgrip strength as the dependent variable (Model R(2)=0.11, p=0.001 non-dominant, R(2)=0.13, p<0.001 dominant). Serum 25OHD was significantly associated with HGD (B(SE)=0.05(0.02), p=0.016) and HGND (B(SE)=0.04(0.02), p=0.019), independent of recreational physical activity. Recreational activity had an association with both hand-grip strength and serum 25OHD, and when each were adjusted to remove this association, 25OHD accounted for 4.3% of HGND and 4.5% of HGD. These results suggest that vitamin D status does have a small but significant association with hand-grip strength in this group of young women. Further investigation in this age group with a randomised controlled trial is justified. This article is part of a Special Issue entitled 'Vitamin D Workshop'.
维生素 D 受体（VDR）在骨骼肌组织中的鉴定以及 VDR 基因缺失小鼠的肌肉力量和发育研究证实了维生素 D 对肌肉功能的作用。在老年人中，已经在一定程度上研究了肌肉力量与维生素 D 状态之间的关系，以预防跌倒，但在年轻人中研究甚少。本横断面研究考虑了生活在新西兰的 137 名年轻女性（19-29 岁）的肌肉力量预测因素。在冬季的最后几个月进行了以下测量：血浆 25OHD、优势手（HGD）和非优势手握力（HGND）（握力测力计）、反向距离跳跃和休闲体育活动（RPA），根据最近的体育活动问卷（RPAQ）进行评估。饮食摄入通过为期四天的食物日记进行测量，身体成分使用空气置换体描仪进行测量。这是一组相对不活跃的女性；总 RPA 每周从 0 到 3.93 小时不等，平均值（SD）为 0.86（0.74）小时，大约 50%由户外活动组成。平均 25OHD 为 54（28）nmol/L，HGD 和 HGND 差异显著（t=6.049，p<0.001），分别为 27.3（5.8）kg 和 25.6（5.7）kg。将总 RPA 和 25OHD 作为因变量输入到握力的线性回归模型中（模型 R（2）=0.11，p=0.001 非优势手，R（2）=0.13，p<0.001 优势手）。血清 25OHD 与 HGD（B（SE）=0.05（0.02），p=0.016）和 HGND（B（SE）=0.04（0.02），p=0.019）显著相关，与休闲体育活动无关。休闲活动与双手握力和血清 25OHD 均有关联，当调整每个关联以消除这种关联时，25OHD 占 HGND 的 4.3%和 HGD 的 4.5%。这些结果表明，在这群年轻女性中，维生素 D 状态与握力确实存在很小但有统计学意义的关联。在该年龄组中进行随机对照试验的进一步研究是合理的。本文是题为“维生素 D 研讨会”的特刊的一部分。
