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1型和2型原发性酒精成瘾者发病年龄的临床重要性。

Clinical importance of age at onset in type 1 and type 2 primary alcoholics.

作者信息

Irwin M, Schuckit M, Smith T L

机构信息

Department of Psychiatry, Veterans Administration Medical Center, San Diego, CA 92161.

出版信息

Arch Gen Psychiatry. 1990 Apr;47(4):320-4. doi: 10.1001/archpsyc.1990.01810160020003.

Abstract

Alcoholics have been proposed to be comprised of subtypes who differ in their age at onset and in type 1 vs type 2 characteristics. This study examined whether the clinical course of primary alcoholics was associated with age at onset as well as the type 1-vs-type 2 classification scheme. Interviews with 171 consecutive primary alcoholic men entering an alcohol treatment program revealed that age at onset of alcoholism was correlated with alcohol, drug, and childhood criminality problem histories. Neither classification of these alcoholics into discrete type 1 and type 2 categories nor placing them along a continuum of type 2 characteristics was consistently associated with severity of clinical histories. These findings underscore the clinical importance of age at onset and suggest the possibility that the type 2 prototype might represent a separate diagnosis, antisocial personality disorder, and not alcoholism itself.

摘要

有人提出,酗酒者可分为不同亚型,这些亚型在起病年龄以及1型与2型特征方面存在差异。本研究探讨了原发性酗酒者的临床病程是否与起病年龄以及1型与2型分类方案相关。对171名连续进入酒精治疗项目的原发性酗酒男性进行访谈后发现,酒精成瘾的起病年龄与酒精、药物及童年犯罪问题史相关。将这些酗酒者分为离散的1型和2型类别,或将他们按照2型特征的连续体排列,均与临床病史的严重程度无一致关联。这些发现强调了起病年龄的临床重要性,并提示2型原型可能代表一种单独的诊断,即反社会人格障碍,而非酒精成瘾本身。

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