Schuckit M A, Irwin M
Br J Addict. 1989 Aug;84(8):869-76. doi: 10.1111/j.1360-0443.1989.tb00759.x.
Predictions inherent in the proposed Type 1/Type 2 continuum of alcoholic subtypes were indirectly explored in 31 sons of primary alcoholic fathers. The fathers' alcoholism was rated on a 0-5 scale utilizing characteristics typical of the Type 2 extreme of the continuum. If a predisposition to Type 2 alcoholism is genetically transmitted, then we would have predicted that the sons of Type 2 alcoholics would be more likely than the sons of Type 1 men to show an earlier onset of drinking, as well as more alcohol and substance intake and associated problems. The results did not support any consistent trend in the correlation between the FHP fathers' alcoholic characteristics and the sons' problem picture. Potential explanations for this finding are discussed including the possibility that the Type 2 extreme might represent a separate diagnostic entity, the antisocial personality disorder, and not alcoholism itself.
在31名原发性酗酒父亲的儿子中，对所提出的酒精亚型1型/2型连续统一体中固有的预测进行了间接探索。利用连续统一体2型极端典型特征，将父亲的酗酒程度按0至5级进行评分。如果2型酗酒的易感性是通过基因遗传的，那么我们可以预测，2型酗酒者的儿子比1型男性的儿子更有可能更早开始饮酒，以及有更多的酒精和物质摄入及相关问题。结果并不支持FHP父亲的酗酒特征与儿子的问题情况之间存在任何一致的相关性趋势。讨论了这一发现的潜在解释，包括2型极端可能代表一个单独的诊断实体，即反社会人格障碍，而不是酗酒本身的可能性。
