血小板平均体积在感染性心内膜炎中增加，治疗后降低。
Mean platelet volume is increased in infective endocarditis and decreases after treatment.
机构信息
Department of Cardiology, Ahi Evran University Education and Research Hospital, Kirsehir, Turkey.
出版信息
Med Princ Pract. 2013;22(3):270-3. doi: 10.1159/000345393. Epub 2012 Dec 5.
OBJECTIVES
The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation in patients with infective endocarditis.
SUBJECTS AND METHODS
Twenty-nine patients with infective endocarditis and 29 healthy subjects were studied. Plasma MPV values in patients and control subjects were measured on admission and after 2 weeks of specific treatment of infective endocarditis.
RESULTS
The MPV was significantly higher among patients with infective endocarditis when compared with the control group (9.86 ± 1.1 vs. 8.0 ± 1.0 fl, respectively; p < 0.01). The MPV values of patients with infective endocarditis decreased significantly after treatment from 9.86 ± 1.1 to 7.86 ± 1.0 fl (p < 0.01). Total platelet counts increased significantly after treatment from 193.4 ± 96.5 × 10(9) to 243.7 ± 92.4 × 10(9) (p = 0.04).
CONCLUSION
MPV values were higher in patients with infective endocarditis and decreased significantly after treatment. Elevated MPV values indicate that patients with infective endocarditis have increased platelet activation and infective endocarditis treatment decreases this platelet activation by decreasing MPV.
目的
本研究旨在评估血小板平均体积（MPV），这是反映感染性心内膜炎患者血小板活化的指标。
受试者和方法
研究纳入 29 例感染性心内膜炎患者和 29 例健康对照者。分别于入院时和感染性心内膜炎特异性治疗 2 周后测量患者和对照组的血浆 MPV 值。
结果
与对照组相比，感染性心内膜炎患者的 MPV 明显升高（分别为 9.86±1.1 比 8.0±1.0 fl，p<0.01）。感染性心内膜炎患者的 MPV 值在治疗后从 9.86±1.1 降至 7.86±1.0 fl（p<0.01）。治疗后血小板计数从 193.4±96.5×10(9)显著增加至 243.7±92.4×10(9)（p=0.04）。
结论
感染性心内膜炎患者的 MPV 值较高，治疗后明显下降。MPV 值升高表明感染性心内膜炎患者血小板活化增加，而感染性心内膜炎治疗可通过降低 MPV 值来减少这种血小板活化。
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