平均血小板体积是血小板活化的一个指标，在二尖瓣狭窄且窦性心律的患者中会升高。
Mean platelet volume, an indicator of platelet activation, is increased in patients with mitral stenosis and sinus rhythm.
作者信息
Varol Ercan, Ozaydin Mehmet, Türker Yasin, Alaca Sule
机构信息
Department of Cardiology, Suleyman Demirel University, Sevket Demirel Kalp Merkezi, Isparta, Turkey.
出版信息
Scand J Clin Lab Invest. 2009;69(6):708-12. doi: 10.3109/00365510903007000.
Systemic thromboembolism is a serious major complication in patients with mitral stenosis. However, the pathogenesis of thromboembolism in mitral stenosis is not fully understood. Previous studies have demonstrated that platelet activation occurs in serum of patients with rheumatic mitral stenosis (MS). The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation, in patients with MS. The study group consisted of 36 patients with MS who were in sinus rhythm. An age and gender matched control group was composed of 30 healthy volunteers. We measured serum MPV values in patients and control subjects. MPV was significantly higher among MS patients with sinus rhythm (SR) when compared with the control group (9.2+/-1.4 vs 8.1+/-0.9 fl respectively; p<0.001). We have shown that MPV was significantly elevated in patients with MS who were in SR compared to control subjects.
系统性血栓栓塞是二尖瓣狭窄患者严重的主要并发症。然而，二尖瓣狭窄中血栓栓塞的发病机制尚未完全明确。既往研究表明，风湿性二尖瓣狭窄（MS）患者血清中会发生血小板活化。本研究旨在评估MS患者中作为血小板活化指标的平均血小板体积（MPV）。研究组由36例窦性心律的MS患者组成。年龄和性别匹配的对照组由30名健康志愿者组成。我们测量了患者和对照者的血清MPV值。与对照组相比，窦性心律（SR）的MS患者的MPV显著更高（分别为9.2±1.4与8.1±0.9 fl；p<0.001）。我们已经表明，与对照者相比，SR的MS患者的MPV显著升高。
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