Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden.
Diabetes Care. 2013 Apr;36(4):962-4. doi: 10.2337/dc12-1331. Epub 2012 Dec 5.
To assess small and large nerve fiber function in people with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes (T2D).
Participants were recruited consecutively from a population-based cohort: NGT (n = 39), IGT (n = 29), and T2D (n = 51). Electrophysiological measures included nerve conduction studies and thermal thresholds. Intraepidermal nerve fiber density (IENFD) in skin biopsies was calculated.
There was no difference between IGT and NGT in sural nerve conduction, IENFD, and thermal thresholds. IENFD was significantly lower in T2D (median = 2.8 fibers/mm [interquartile range 1.1-4.7 fibers/mm]) than NGT individuals (4.5 fibers/mm [3.4-6.1 fibers/mm]; P < 0.05). T2D participants had poorer nerve conduction and higher heat thresholds than NGT and IGT.
Large and small nerve function in people with IGT did not differ from those with NGT. Our finding does not support the existence of neuropathy in a prediabetic stage.
评估糖耐量正常（NGT）、糖耐量受损（IGT）和 2 型糖尿病（T2D）人群中小、大神经纤维功能。
参与者从人群队列中连续招募：NGT（n=39）、IGT（n=29）和 T2D（n=51）。电生理测量包括神经传导研究和热阈值。计算皮肤活检的表皮内神经纤维密度（IENFD）。
IGT 与 NGT 之间的腓肠神经传导、IENFD 和热阈值没有差异。T2D 患者的 IENFD 明显低于 NGT 个体（中位数=2.8 纤维/mm[四分位距 1.1-4.7 纤维/mm]）（4.5 纤维/mm[3.4-6.1 纤维/mm]；P<0.05）。T2D 参与者的神经传导较差，热阈值较高，与 NGT 和 IGT 相比。
IGT 患者的大、小神经功能与 NGT 患者无差异。我们的发现不支持在糖尿病前期存在神经病变。
