A-to-I RNA 编辑在温度适应中的作用。
A role for A-to-I RNA editing in temperature adaptation.
机构信息
Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
出版信息
Physiology (Bethesda). 2012 Dec;27(6):362-9. doi: 10.1152/physiol.00029.2012.
Abstract
A-to-I RNA editing can recode mRNAs, giving organisms the option to express diverse, functionally distinct protein isoforms. Here, we propose that RNA editing is inherently geared for temperature adaptation because it tends to recode to smaller, less stabilizing amino acids. Studies on how editing affects protein function support this idea.
摘要
A 到 I 的 RNA 编辑可以对 mRNA 进行重新编码，使生物体能够选择表达多样化、功能不同的蛋白质同工型。在这里，我们提出 RNA 编辑本质上是为了适应温度而产生的，因为它倾向于重新编码为更小、更不稳定的氨基酸。关于编辑如何影响蛋白质功能的研究支持了这一观点。
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