Arnhold-Schneider M, Schall H
Univ. Hals-Nasen-Ohren-Klinik Ulm.
Laryngorhinootologie. 1990 Feb;69(2):91-7. doi: 10.1055/s-2007-998151.
The study is concerned with the occurrence and distribution of squamous epithelial areas in the human larynx as well as with the question as to whether inferences with regard to the development of inner laryngeal carcinomas can be made from their location. For this purpose, macroscopic epithelial staining was carried out on 104 cadaver larynxes and the results compared with the tumor location established in macroscopic serial sections of approximately 100 surgical preparations of extirpated larynxes. Special interest was devoted above all to the occurrence of squamous epithelium outside the vocal cord level. The authors found special sites of predilection for carcinogenesis which showed an astonishingly striking correlation with the distribution of the squamous epithelium found in the interior of the larynx in all age groups. Direct carcinogenesis from healthy squamous epithelium is discussed as well as the development of cancer from a metaplastic transformation of ciliated epithelium into squamous epithelium. The results constitute a contribution to early diagnosis of inner tumors of the larynx, since on the basis of the results it appears to be indicated that increased specific attention needs to be paid to the parts of the mucosa which display areas of squamous epithelium with a certain regularity in microlaryngoscopy.
这项研究关注人类喉部鳞状上皮区域的发生与分布，以及能否根据其位置对喉内癌的发展做出推断。为此，对104个尸体喉部进行了宏观上皮染色，并将结果与在大约100个切除喉部手术标本的宏观连续切片中确定的肿瘤位置进行比较。特别关注的是声带水平以外鳞状上皮的出现情况。作者发现了致癌的特殊偏好部位，这些部位与所有年龄组喉部内部发现的鳞状上皮分布呈现出惊人的显著相关性。讨论了健康鳞状上皮的直接致癌作用以及纤毛上皮化生为鳞状上皮后癌症的发展。这些结果有助于喉内肿瘤的早期诊断，因为基于这些结果，似乎表明在显微喉镜检查中需要对黏膜中以一定规律显示鳞状上皮区域的部位给予更多的特别关注。
