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具有诱导顺铂耐药神经母细胞瘤细胞凋亡特性的乙烯桥连四氮杂环卡宾钯（II）、铂（II）和金（III）配合物的合成、表征及生物医学评价

Synthesis, characterization, and biomedical evaluation of ethylene-bridged tetra-NHC Pd(ii), Pt(ii) and Au(iii) complexes, with apoptosis-inducing properties in cisplatin-resistant neuroblastoma cells.

作者信息

Büchele Wolfgang R E, Schlachta Tim P, Gebendorfer Andreas L, Pamperin Jenny, Richter Leon F, Sauer Michael J, Prokop Aram, Kühn Fritz E

机构信息

Technical University of Munich, School of Natural Sciences, Department of Chemistry and Catalysis Research Center, Molecular Catalysis Lichtenbergstraße 4 85748 Garching Germany

Department of Pediatric Oncology/Hematology, Helios Clinics Schwerin Wismarsche Straße 393-397 19055 Schwerin Germany

出版信息

RSC Adv. 2024 Mar 27;14(15):10244-10254. doi: 10.1039/d4ra01195c. eCollection 2024 Mar 26.

DOI:10.1039/d4ra01195c
PMID:38544944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10967698/
Abstract

Synthesis and characterization of the first two cyclic ethylene-bridged tetradentate NHC ligands, with an unsaturated (imidazole) and saturated backbone (2-imidazoline), are described. Complexes of both ligands containing palladium(ii) have been obtained. For platinum(ii) and gold(iii), only the unsaturated tetracarbene complexes could be isolated. The attempts to synthesize a methylene-bridged 2-imidazoline macrocycle are also described. Furthermore, a novel bisimidazolinium ligand precursor and its open-chain Pd and Pt tetracarbene complexes are obtained. Finally, it is shown that the unsaturated gold(iii) tetracarbene is able to induce apoptosis in malignant SK-N-AS neuroblastoma cells the mitochondrial and ROS pathway and overcomes resistance to cisplatin .

摘要

描述了前两种具有不饱和（咪唑）和饱和主链（2-咪唑啉）的环状乙烯桥连四齿NHC配体的合成与表征。已获得两种含钯（II）配体的配合物。对于铂（II）和金（III），仅分离出不饱和四碳烯配合物。还描述了合成亚甲基桥连2-咪唑啉大环的尝试。此外，获得了一种新型双咪唑鎓配体前体及其开链钯和铂四碳烯配合物。最后表明，不饱和金（III）四碳烯能够通过线粒体和ROS途径诱导恶性SK-N-AS神经母细胞瘤细胞凋亡，并克服对顺铂的耐药性。

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