Max-Planck-Institut für Polymerforschung, Ackermannweg 10, Mainz, 55128, Germany.
Macromol Rapid Commun. 2013 Feb 25;34(4):310-29. doi: 10.1002/marc.201200634. Epub 2012 Dec 7.
Photoremovable protecting groups (PRPGs) are applied to organic surfaces, thin polymer films, and hydrogels to achieve light-based remote control of their (bio)chemical and physical properties. These can be localized (i.e. patterned), tunable by exposure dose, and generated on-demand. Using PRPGs with independent response to different wavelengths, multifunctional materials with a number of individually addressable functional states can be generated. Light-triggered polymerization, crosslinking, and degradation processes as well as release of attached molecules can be realized. Light-responsive surfaces and materials based on PRPGs open interesting possibilities for the next generation of instructive materials for cell culture and tissue regeneration.
光致脱保护基团 (PRPGs) 被应用于有机表面、聚合物薄膜和水凝胶中，以实现对它们的（生物）化学和物理性质的基于光的远程控制。这些基团可以是局部的（即图案化的），可以通过曝光剂量进行调节，并按需生成。使用对不同波长具有独立响应的 PRPGs，可以生成具有多个可单独寻址功能状态的多功能材料。可以实现光触发聚合、交联和降解过程以及附着分子的释放。基于 PRPGs 的光响应表面和材料为下一代用于细胞培养和组织再生的指导材料开辟了有趣的可能性。
