Parmar Riddhi, Kalaria Amankumar N, Patel Keval A
Department of Pathology, All India Institute of Medical Sciences, Rajkot, Rajkot, IND.
Department of Pathology, Swaminarayan Institute of Medical Sciences & Research, Kalol, IND.
Cureus. 2024 Apr 29;16(4):e59328. doi: 10.7759/cureus.59328. eCollection 2024 Apr.
The fifth edition of the World Health Organization (WHO) classification introduces new diagnostic methods based on genetic alterations, providing insight into the molecular basis of lesions. As a result, the classification system has evolved, new entities have been introduced, and existing entities have been reclassified. Oncocytic lesions of salivary glands are a group of neoplastic conditions characterized by the presence of oncocytic cells. These lesions present a diagnostic challenge due to their overlapping histological features. Therefore, a comprehensive evaluation, including morphological, immunohistochemical, and molecular analysis, is crucial for accurate diagnosis and appropriate management. Accurate classification of salivary gland pathologies is essential for selecting the appropriate treatment methods and predicting outcomes. The introduction of new therapeutic approaches, such as targeted therapies for malignant salivary gland tumors, has improved patient outcomes. However, to effectively implement these therapies in clinical practice, a clear classification of lesions is necessary.
世界卫生组织（WHO）分类的第五版引入了基于基因改变的新诊断方法，从而深入了解病变的分子基础。因此，分类系统不断演变，引入了新的实体，并对现有实体进行了重新分类。涎腺嗜酸性细胞病变是一组以嗜酸性细胞存在为特征的肿瘤性疾病。这些病变因其组织学特征重叠而带来诊断挑战。因此，包括形态学、免疫组织化学和分子分析在内的综合评估对于准确诊断和恰当处理至关重要。涎腺病理学的准确分类对于选择合适的治疗方法和预测预后至关重要。新治疗方法的引入，如针对恶性涎腺肿瘤的靶向治疗，改善了患者的预后。然而，要在临床实践中有效实施这些治疗，明确的病变分类是必要的。
