Salerno Emilio, Abati Silvio, Arrigoni Gianluigi, Finocchiaro Daniela, Gastaldi Giorgio, Lissoni Alessandra, Galli Andrea, Trimarchi Matteo
Vita-Salute San Raffaele University, Milan, Italy.
Department of Otolaryngology Head and Neck Surgery, IRCCS San Raffaele Hospital, Milan, Italy.
Clin Exp Dent Res. 2025 Aug;11(4):e70200. doi: 10.1002/cre2.70200.
The primary objective of this study is to report and analyze two rare cases of secretory carcinoma (SC) of the minor salivary glands, focusing on their diagnostic and therapeutic work-up. The study aims to enhance scientific knowledge about SC, which is crucial for developing targeted therapies and ensuring precise diagnosis, especially differentiating it from acinic cell carcinoma (ACC).
The study involved a detailed examination of two patients diagnosed with SC of the minor salivary glands. Clinical examinations, histological investigations, and immunohistochemical analyses were conducted. The treatment approach included surgical excision of the lesions followed by regular follow-ups to monitor for recurrence. Immunohistochemical analysis was performed to identify the presence of markers such as GATA3, SOX-10, NTRK, mammaglobin, and others.
Two cases are shown: a case of a 76-year-old male with a lesion in the hard palate was initially misdiagnosed as leukoplakia. After surgical excision and histological examination, the lesion was identified as SC. The patient underwent follow-up examinations, including MRI and CT scans, which showed no recurrence, and another case of a 39-year-old female with a nodule in the superior left vestibule underwent surgery to remove the nodule. Histological and immunohistochemical analyses confirmed SC, showing a high proliferation index and presence of the ETV6-NTRK3 gene fusion. Follow-up imaging showed no signs of disease recurrence.
The study underscores the importance of precise diagnosis and differentiation of SC from ACC. Surgical excision followed by regular monitoring is effective in managing SC. Immunohistochemical and molecular analyses are crucial for accurate diagnosis. The findings contribute to the growing body of evidence on SC and highlight the potential for developing more targeted therapies. Further research is needed to establish clear guidelines for follow-up duration and treatment protocols.
本研究的主要目的是报告并分析两例罕见的小涎腺分泌性癌（SC）病例，重点关注其诊断和治疗过程。该研究旨在增进关于SC的科学知识，这对于开发靶向治疗方法和确保准确诊断至关重要，尤其是将其与腺泡细胞癌（ACC）区分开来。
该研究对两名被诊断为小涎腺SC的患者进行了详细检查。进行了临床检查、组织学研究和免疫组化分析。治疗方法包括手术切除病变，随后定期随访以监测复发情况。进行免疫组化分析以确定GATA3、SOX-10、NTRK、乳腺珠蛋白等标志物的存在情况。
展示了两个病例：一例是一名76岁男性，硬腭有病变，最初被误诊为白斑。手术切除和组织学检查后，病变被确定为SC。患者接受了包括MRI和CT扫描在内的随访检查，未显示复发；另一例是一名39岁女性，左上前庭有一个结节，接受了手术切除结节。组织学和免疫组化分析证实为SC，显示高增殖指数和ETV6-NTRK3基因融合的存在。随访成像未显示疾病复发迹象。
该研究强调了准确诊断SC并将其与ACC区分开来的重要性。手术切除后定期监测对SC的治疗有效。免疫组化和分子分析对于准确诊断至关重要。这些发现为关于SC的证据积累做出了贡献，并突出了开发更具靶向性治疗方法的潜力。需要进一步研究以建立关于随访持续时间和治疗方案的明确指南。
