Malyshev A V, Zakharov A M, Sarkisova K Iu, Dubynin V A
Zh Vyssh Nerv Deiat Im I P Pavlova. 2012 Sep-Oct;62(5):580-90.
Learning and reverse learning in a complex maze, behavior in the open field test, novelty-suppressed feeding test, and forced swimming test were studies in WAG/Rij and Wistar rats. As compared with Wistar rats, WAG/Rij rats more slowly learned the spatial task, more slowly performed in the learning and reverse learning tasks, and made more errors in the complex maze (18% of WAG/Rij rats didn't reach learning criterion). Moreover, WAG/Rij rats exhibited reduced grooming reactions in the open field test, longer latency of approaching to food in the novel open field, reduced amount of food consumed in the home cage in the novelty-suppressed feeding test, and increased immobility time in the forced swimming test. The results suggest cognitive impaiment in WAG/Rij rats with depression-like behavior.
在WAG/Rij和Wistar大鼠中研究了复杂迷宫中的学习和逆向学习、旷场试验中的行为、新奇抑制摄食试验以及强迫游泳试验。与Wistar大鼠相比，WAG/Rij大鼠学习空间任务的速度更慢，在学习和逆向学习任务中的表现更慢，并且在复杂迷宫中犯的错误更多（18%的WAG/Rij大鼠未达到学习标准）。此外，WAG/Rij大鼠在旷场试验中梳理反应减少，在新奇旷场中接近食物的潜伏期延长，在新奇抑制摄食试验中在笼内消耗的食物量减少，在强迫游泳试验中不动时间增加。结果表明具有抑郁样行为的WAG/Rij大鼠存在认知障碍。
