Schröter Paula, Lupp Bettina, Ganter Martin, Distl Ottmar
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany.
Berl Munch Tierarztl Wochenschr. 2012 Nov-Dec;125(11-12):476-81.
The objective of this study was to demonstrate that bovine neonatal pancytopenia (BNP) can be prevented when intake of maternal colostrum is prevented in a dairy farm with verified BNP cases. A group of 30 female calves was fed with a colostrum substitute instead of maternal colostrum (group A) whereas the control group of 30 female calves was fed with the colostrum of their own mothers (group B). The female calves were randomly assigned to groups A or B. All 60 calves were daily blood sampled in the first eleven days of life, afterwards up to the age of three weeks one blood sample was taken every other day. All blood samples were analyzed for thrombocyte and leucocyte counts. In addition, 113 calves of both sexes, which were born during the trial period, were blood sampled once at 6-10 days old. In group A, no BNP positive calf was verified. In group B, eight calves with a significant decrease of thrombocyte and leucocyte counts were observed. Only one of these eight calves had clinical signs consistent with BNP and the other seven calves were classified as subclinical BNP cases. Of the other 113 contemporary calves, eleven animals had clinical signs of BNP accompanied by a decrease of thrombocyte and leucocyte counts and four of these eleven calves died due to BNP. Our results revealed that replacement of maternal colostrum can prevent subclinical and clinical cases of BNP as well as losses due to BNP in a dairy herd with verified BNP-cases and in addition, that colostrum from these cows was the major risk factor for BNP in this dairy herd.
本研究的目的是证明，在一个已确诊存在牛新生儿全血细胞减少症（BNP）病例的奶牛场，当阻止犊牛摄入母体初乳时，BNP是可以预防的。一组30头雌性犊牛用初乳替代品喂养，而非母体初乳（A组），而另一组30头雌性犊牛的对照组则用其生母的初乳喂养（B组）。雌性犊牛被随机分配到A组或B组。所有60头犊牛在出生后的前11天每天进行采血，之后直至三周龄，每隔一天采集一次血样。所有血样均分析血小板和白细胞计数。此外，在试验期间出生的113头雌雄犊牛在6至10日龄时均采血一次。在A组中，未发现BNP阳性犊牛。在B组中，观察到8头犊牛的血小板和白细胞计数显著下降。这8头犊牛中只有1头有与BNP相符的临床症状，其他7头犊牛被归类为亚临床BNP病例。在其他113头同期出生的犊牛中，11头动物有BNP的临床症状，同时伴有血小板和白细胞计数下降，这11头犊牛中有4头因BNP死亡。我们的结果表明，在一个已确诊BNP病例的奶牛群中，用初乳替代品替代母体初乳可以预防亚临床和临床BNP病例以及因BNP造成的损失，此外，这些母牛的初乳是该奶牛群中BNP的主要风险因素。
