Tamura A, Kirino T, Sano K, Takagi K, Oka H
Department of Neurosurgery, Teikyo University School of Medicine, Tokyo, Japan.
Brain Res. 1990 Feb 26;510(1):154-7. doi: 10.1016/0006-8993(90)90744-v.
Following occlusion of the left middle cerebral artery in the rat, marked atrophy was observed in the ipsilateral substantia nigra in and after the second week. The mechanism of this neuropathological change in the substantia nigra, which is remote from the site of infarction, may be explained by transsynaptic, neurotransmitter-mediated disinhibition as a result of infarction of the striatum.
大鼠左侧大脑中动脉闭塞后，在第二周及之后同侧黑质中观察到明显萎缩。黑质中这种神经病理变化的机制，其远离梗死部位，可能是由于纹状体梗死导致的跨突触、神经递质介导的去抑制作用所致。
