Section of Endocrinology, Andrology and Internal Medicine, Department of Medical and Pediatric Sciences, University of Catania, Building 4, Room 2C17, Via S. Sofia 78, 95123 Catania, Italy.
Nat Rev Urol. 2013 Jan;10(1):55-62. doi: 10.1038/nrurol.2012.234. Epub 2012 Dec 11.
Several empirical treatments have been proposed to treat idiopathic infertility in men, including follicle-stimulating hormone (FSH). FSH administration is effective in patients with hypogonadotropic hypogonadism, which suggests it might be useful in patients with oligozoospermia who have normal FSH levels. Indeed, many studies have evaluated the efficacy of FSH administration in these patients, several of which have shown improvements in sperm parameters. By contrast, other studies have not reported any significant effect of FSH administration on conventional sperm parameters, although some of have reported the normalization of spermatozoon ultrastructural morphology, as well as reductions in DNA fragmentation, production of reactive oxygen species and aneuploidy. Contemporary studies suggest that the response to FSH treatment in oligozoospermic patients might, at least partially, reflect polymorphisms of the FSH receptor gene. Thus, FSH administration in oligozoospermic men with normal serum FSH levels might be efficacious only in selected patients. For this reason, additional studies are needed to determine the predictive factors and clinical conditions that can be used to identify patients who could benefit from FSH treatment.
已经提出了几种治疗男性特发性不孕的经验性治疗方法，包括卵泡刺激素（FSH）。FSH 治疗在促性腺激素低下性性腺功能减退症患者中有效，这表明它可能对 FSH 水平正常的少精子症患者有用。事实上，许多研究已经评估了 FSH 治疗这些患者的疗效，其中一些研究显示精子参数有所改善。相比之下，其他研究并未报告 FSH 治疗对常规精子参数有任何显著影响，尽管一些研究报告了精子超微结构形态的正常化，以及 DNA 碎片化、活性氧产生和非整倍体的减少。当代研究表明，少精子症患者对 FSH 治疗的反应至少部分反映了 FSH 受体基因的多态性。因此，在 FSH 水平正常的少精子症男性中使用 FSH 治疗可能仅对某些患者有效。因此，需要进一步的研究来确定预测因素和临床情况，以便能够识别可能从 FSH 治疗中受益的患者。
