Zhang Zhe, Yang Yu-Zhuo, Zhang Hai-Tao, Xi Yu, Wang Cun-Tong, Liu De-Feng, Mao Jia-Ming, Lin Hao-Cheng, Tang Wen-Hao, Zhao Lian-Ming, Zhang Xian-Sheng, Dai Yu-Tian, Jiang Hui
Department of Urology, Peking University Third Hospital, Beijing, China.
Department of Reproductive Medicine Center, Peking University Third Hospital, Beijing, China.
Basic Clin Androl. 2023 Feb 16;33(1):8. doi: 10.1186/s12610-022-00177-5.
The coronavirus disease 2019 (COVID-19) outbreak has had a widespread and profound impact on people's mental health. The factors associated with mental symptoms among men diagnosed with infertility, a disease closely related to psychological conditions, remain unclear. The aim of this study is to investigate the risk factors associated with mental symptoms among infertile Chinese men during the pandemic.
A total of 4,098 eligible participants were recruited in this cross-sectional, nationwide study, including 2,034 (49.6%) with primary infertility and 2,064 (50.4%) with secondary infertility. The prevalence of mental health conditions was 36.3%, 39.6%, and 6.7% for anxiety, depression, and post-pandemic stress, respectively. Sexual dysfunction is associated with a higher risk with adjusted odds ratios (ORs) of 1.40 for anxiety, 1.38 for depression, and 2.32 for stress. Men receiving infertility drug therapy displayed a higher risk for anxiety (adjusted OR, 1.31) and depression (adjusted OR, 1.28) symptoms, while those receiving intrauterine insemination had a lower risk of anxiety (adjusted OR, 0.56) and depression (adjusted OR, 0.55) symptoms.
The COVID-19 pandemic has had a significant psychological impact on infertile men. Several psychologically vulnerable populations were identified, including individuals with sexual dysfunction, respondents receiving infertility drug therapy, and those experiencing control measures for COVID-19. The findings provide a comprehensive profile of the mental health status of infertile Chinese men during the COVID-19 outbreak and provide potential psychological intervention strategies.
2019年冠状病毒病（COVID-19）疫情对人们的心理健康产生了广泛而深远的影响。与心理状况密切相关的不育症男性患者出现精神症状的相关因素尚不清楚。本研究旨在调查疫情期间中国不育男性出现精神症状的危险因素。
在这项全国性的横断面研究中，共招募了4098名符合条件的参与者，其中原发性不育者2034名（49.6%），继发性不育者2064名（50.4%）。焦虑、抑郁和疫情后应激的心理健康状况患病率分别为36.3%、39.6%和6.7%。性功能障碍与更高的风险相关，焦虑、抑郁和应激的调整后比值比（OR）分别为1.40、1.38和2.32。接受不育药物治疗的男性出现焦虑（调整后OR，1.31）和抑郁（调整后OR，1.28）症状的风险更高，而接受宫内人工授精的男性出现焦虑（调整后OR，0.56）和抑郁（调整后OR，0.55）症状的风险较低。
COVID-19疫情对不育男性产生了重大的心理影响。确定了几个心理脆弱群体，包括性功能障碍患者、接受不育药物治疗的受访者以及经历COVID-19防控措施的人群。研究结果全面描述了COVID-19疫情期间中国不育男性的心理健康状况，并提供了潜在的心理干预策略。
