Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China.
J Mater Sci Mater Med. 2012 Oct;23(10):2413-23. doi: 10.1007/s10856-012-4692-5. Epub 2012 Jun 6.
In this study, a mineralized collagen coating was electrolytically deposited onto titanium. The results showed that the mineralized collagen coatings with dense or porous morphology could be obtained. The mineral phase was mainly hydroxyapatite. In vitro evaluation showed the mineralized collagen coatings were stable in Kokubo's simulated body fluid, and displayed a good cytocompatibility in the cell multiplication test. The mineralized collagen coatings loaded with vancomycin hydrochloride showed an inhibitory effect on the growth of S. aureus. The present mineralized collagen coating demonstrates good suitability for surface modification of orthopedic metal implants.
本研究通过电解的方法在钛表面沉积矿化胶原涂层。结果表明，可以获得致密或多孔形貌的矿化胶原涂层。矿相主要为羟基磷灰石。体外评价表明，矿化胶原涂层在 Kokubo 模拟体液中稳定，细胞增殖试验显示其具有良好的细胞相容性。载盐酸万古霉素的矿化胶原涂层对金黄色葡萄球菌的生长具有抑制作用。本矿化胶原涂层适合用作骨科金属植入物的表面改性。
