Department of Cardio-thoracic Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands,
Neth Heart J. 2013 Jan;21(1):21-7. doi: 10.1007/s12471-012-0364-9.
The disease burden of patients with severe aortic stenosis is not often explored, while the incidence is increasing and many patients who have an indication for aortic valve replacement are not referred for surgery. We studied the quality of life of 191 patients with severe aortic stenosis, hypothesising that symptomatic patients have a far worse quality of life than the general population, which could enforce the indication for surgery.
The SF-36v2 Health Survey was completed by 191 consecutive patients with symptomatic or asymptomatic severe aortic stenosis.
Asymptomatic patients (n = 59) had health scores comparable with the general Dutch population but symptomatic patients (n = 132) scored significantly lower across different age categories. Physical functioning, general health and vitality were impaired, as well as social functioning and emotional well-being. There was no relation between degree of stenosis and physical or mental health scores.
Both physical and emotional problems have a major impact on normal daily life and social functioning of symptomatic patients with severe aortic stenosis, regardless of age. If the aortic stenosis is above the 'severe' threshold, the degree of stenosis does not predict disease burden. These results encourage to reconsider a conservative approach in symptomatic patients with severe aortic stenosis. Using the SF-36v2 Health Survey together with this study, an individual patient's quality of life profile can be assessed and compared with the patient group or with the general population. This can assist in decision making for the individual patient.
严重主动脉瓣狭窄患者的疾病负担往往未得到充分探讨,而其发病率正在上升,许多有主动脉瓣置换指征的患者并未接受手术治疗。我们研究了 191 例严重主动脉瓣狭窄患者的生活质量,假设有症状的患者生活质量远差于普通人群,这可能会加强手术指征。
191 例有症状或无症状的严重主动脉瓣狭窄患者连续完成了 SF-36v2 健康调查。
无症状患者(n=59)的健康评分与荷兰普通人群相当,但有症状的患者(n=132)在不同年龄组的评分显著较低。身体机能、总体健康和活力受损,社会功能和情绪健康也受到影响。狭窄程度与身体或心理健康评分之间没有关系。
无论年龄大小,严重主动脉瓣狭窄有症状患者的身体和情绪问题都会对其日常生活和社会功能产生重大影响。如果主动脉瓣狭窄超过“严重”阈值,则狭窄程度并不能预测疾病负担。这些结果鼓励重新考虑对严重主动脉瓣狭窄有症状患者的保守治疗方法。使用 SF-36v2 健康调查并结合本研究,可以评估个体患者的生活质量状况,并将其与患者群体或普通人群进行比较。这有助于为个体患者做出决策。