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本文引用的文献

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The effect of aortic valve replacement on quality of life in symptomatic patients with severe aortic stenosis.主动脉瓣置换术对有症状的重度主动脉瓣狭窄患者生活质量的影响。
Neth Heart J. 2013 Jan;21(1):28-35. doi: 10.1007/s12471-012-0362-y.
2
Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS).《心脏瓣膜病管理指南(2012年版)》:欧洲心脏病学会(ESC)和欧洲心胸外科学会(EACTS)心脏瓣膜病管理联合工作组
Eur J Cardiothorac Surg. 2012 Oct;42(4):S1-44. doi: 10.1093/ejcts/ezs455. Epub 2012 Aug 25.
3
Clinical course of patients diagnosed with severe aortic stenosis in the Rotterdam area: insights from the AVARIJN study.在鹿特丹地区诊断为严重主动脉瓣狭窄的患者的临床病程:AVARIJN 研究的见解。
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Quality of life after cardiac surgery: underresearched research.心脏手术后的生活质量:研究不足的研究领域。
Interact Cardiovasc Thorac Surg. 2011 Nov;13(5):511-4. doi: 10.1510/icvts.2011.276311. Epub 2011 Aug 1.
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One year follow-up of the multi-centre European PARTNER transcatheter heart valve study.多中心欧洲 PARTNER 经导管心脏瓣膜研究的一年随访结果。
Eur Heart J. 2011 Jan;32(2):148-57. doi: 10.1093/eurheartj/ehq427. Epub 2010 Nov 12.
6
Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial.瑞舒伐他汀降脂治疗对主动脉瓣狭窄进展的影响:主动脉瓣狭窄进展观察研究的结果:评价瑞舒伐他汀的效果(ASTROMER)试验。
Circulation. 2010 Jan 19;121(2):306-14. doi: 10.1161/CIRCULATIONAHA.109.900027. Epub 2010 Jan 4.
7
Therapeutic decisions for patients with symptomatic severe aortic stenosis: room for improvement?有症状的重度主动脉瓣狭窄患者的治疗决策:仍有改进空间?
Eur J Cardiothorac Surg. 2009 Jun;35(6):953-7; discussion 957. doi: 10.1016/j.ejcts.2009.01.043. Epub 2009 Mar 20.
8
Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis.辛伐他汀与依折麦布强化降脂治疗主动脉瓣狭窄
N Engl J Med. 2008 Sep 25;359(13):1343-56. doi: 10.1056/NEJMoa0804602. Epub 2008 Sep 2.
9
Unoperated patients with severe aortic stenosis.患有严重主动脉瓣狭窄的未接受手术治疗的患者。
J Am Coll Cardiol. 2007 Nov 13;50(20):2018-9. doi: 10.1016/j.jacc.2007.08.011. Epub 2007 Oct 29.
10
Aortic valve replacement in octogenarians: risk factors for early and late mortality.八旬老人主动脉瓣置换术:早期和晚期死亡的危险因素
Ann Thorac Surg. 2007 May;83(5):1651-6; discussion 1656-7. doi: 10.1016/j.athoracsur.2006.09.068.

严重主动脉瓣狭窄患者的生活质量。

Quality of life among patients with severe aortic stenosis.

机构信息

Department of Cardio-thoracic Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands,

出版信息

Neth Heart J. 2013 Jan;21(1):21-7. doi: 10.1007/s12471-012-0364-9.

DOI:10.1007/s12471-012-0364-9
PMID:23229811
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3528854/
Abstract

BACKGROUND

The disease burden of patients with severe aortic stenosis is not often explored, while the incidence is increasing and many patients who have an indication for aortic valve replacement are not referred for surgery. We studied the quality of life of 191 patients with severe aortic stenosis, hypothesising that symptomatic patients have a far worse quality of life than the general population, which could enforce the indication for surgery.

METHODS

The SF-36v2 Health Survey was completed by 191 consecutive patients with symptomatic or asymptomatic severe aortic stenosis.

RESULTS

Asymptomatic patients (n = 59) had health scores comparable with the general Dutch population but symptomatic patients (n = 132) scored significantly lower across different age categories. Physical functioning, general health and vitality were impaired, as well as social functioning and emotional well-being. There was no relation between degree of stenosis and physical or mental health scores.

CONCLUSIONS

Both physical and emotional problems have a major impact on normal daily life and social functioning of symptomatic patients with severe aortic stenosis, regardless of age. If the aortic stenosis is above the 'severe' threshold, the degree of stenosis does not predict disease burden. These results encourage to reconsider a conservative approach in symptomatic patients with severe aortic stenosis. Using the SF-36v2 Health Survey together with this study, an individual patient's quality of life profile can be assessed and compared with the patient group or with the general population. This can assist in decision making for the individual patient.

摘要

背景

严重主动脉瓣狭窄患者的疾病负担往往未得到充分探讨,而其发病率正在上升,许多有主动脉瓣置换指征的患者并未接受手术治疗。我们研究了 191 例严重主动脉瓣狭窄患者的生活质量,假设有症状的患者生活质量远差于普通人群,这可能会加强手术指征。

方法

191 例有症状或无症状的严重主动脉瓣狭窄患者连续完成了 SF-36v2 健康调查。

结果

无症状患者(n=59)的健康评分与荷兰普通人群相当,但有症状的患者(n=132)在不同年龄组的评分显著较低。身体机能、总体健康和活力受损,社会功能和情绪健康也受到影响。狭窄程度与身体或心理健康评分之间没有关系。

结论

无论年龄大小,严重主动脉瓣狭窄有症状患者的身体和情绪问题都会对其日常生活和社会功能产生重大影响。如果主动脉瓣狭窄超过“严重”阈值,则狭窄程度并不能预测疾病负担。这些结果鼓励重新考虑对严重主动脉瓣狭窄有症状患者的保守治疗方法。使用 SF-36v2 健康调查并结合本研究,可以评估个体患者的生活质量状况,并将其与患者群体或普通人群进行比较。这有助于为个体患者做出决策。