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经皮穿刺椎体间融合术联合附加经皮椎弓根动态稳定治疗腰椎间盘突出症:10 年随访无临床获益。

Sequestrectomy with additional transpedicular dynamic stabilization for the treatment of lumbar disc herniation: no clinical benefit after 10 years follow-up.

机构信息

Clinic for Orthopaedics, Center for Musculoskeletal Surgery, CHARITÉ-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

出版信息

Spine (Phila Pa 1976). 2013 May 15;38(11):887-95. doi: 10.1097/BRS.0b013e31828150a6.

Abstract

STUDY DESIGN

Single-center prospective study.

OBJECTIVE

Clinical and radiological long-term evaluation of the effects of transpedicular dynamic stabilization after sequestrectomy.

SUMMARY OF BACKGROUND DATA

Short- and mid-term investigations have shown that additional dynamic stabilization is appropriate to prevent progression of initial segment degeneration after sequestrectomy and associated with superior clinical outcome compared with sequestrectomy alone. Long-term data are missing.

METHODS

Eighty-four patients with symptomatic disc herniation and initial osteochondrosis (Modic = I°) of the lumbar spine underwent sequestrectomy. Additional dynamic stabilization was performed in 35 subjects (group D); the remaining 49 subjects were treated with sequestrectomy alone (group S). Clinical (Oswestry Low Back Pain Disability Questionnaire, Version 2.0; visual analogue scale) and radiological (plain and extension-flexion radiographs and magnetic resonance images) parameters were collected preoperatively, at 3 months postoperatively, as well as at a mean follow-up of 2.8 and 10.2 years.

RESULTS

Twenty-nine of 35 (83%, group D) and 38 of 49 (78%, group S) patients were available at the final follow-up. Reoperation rate in group D was 34% (10/29) due to implant failures or progression of degeneration at the index or the adjacent segments. In group S, 5 of 38 (13%) underwent further operation because of a reprolapse or progression of degeneration of the index level. In the remaining patients, clinical scores (Oswestry Low Back Pain Disability Questionnaire, Version 2.0; and visual analogue scale) improved significantly, with similar results in both groups at the final follow-up. The rate of progression of disc degeneration was lower when the patients were also dynamically stabilized than sequestrectomy alone, but the rate of adjacent segment degeneration superior to the operated segment was significantly higher in group D.

CONCLUSION

Additional dynamic stabilization does not lead to a clinical benefit in patients with symptomatic disc herniation and initial segment degeneration compared with sequestrectomy alone after a long-term follow-up. Because of this and the high rate of necessary reoperations, we do not recommend this surgical strategy for this indication.

LEVEL OF EVIDENCE

摘要

研究设计

单中心前瞻性研究。

目的

对经皮穿刺动态稳定术后切除骨赘的临床和影像学长期疗效进行评估。

背景资料概要

短期和中期研究表明,在切除骨赘后,附加动态稳定有助于防止初始节段退变的进展,并与单纯切除骨赘相比,具有更好的临床疗效。目前还缺乏长期数据。

方法

84 例患有症状性椎间盘突出症和腰椎初始骨软骨病(Modic=I°)的患者接受了切除骨赘手术。其中 35 例患者(D 组)进行了附加动态稳定治疗,其余 49 例患者仅接受了切除骨赘手术(S 组)。收集术前、术后 3 个月以及平均 2.8 年和 10.2 年的临床(Oswestry 下腰痛残疾问卷,第 2.0 版;视觉模拟评分)和影像学(平片和屈伸位片及磁共振成像)参数。

结果

D 组有 29 例(83%)和 S 组有 38 例(78%)患者在最终随访时可获得。由于植入物失败或指数或相邻节段退变进展,D 组中有 10 例(34%)患者需要再次手术。在 S 组中,有 5 例(13%)患者因指数水平的复发性椎间盘突出或退变进展而再次手术。在其余患者中,临床评分(Oswestry 下腰痛残疾问卷,第 2.0 版;视觉模拟评分)显著改善,两组在最终随访时的结果相似。与单纯切除骨赘相比,当患者同时进行动态稳定时,椎间盘退变的进展速度较低,但 D 组中相邻节段退变的发生率明显高于手术节段。

结论

在长期随访中,与单纯切除骨赘相比,对于患有症状性椎间盘突出症和初始节段退变的患者,附加动态稳定治疗并未带来临床获益。由于这一点以及需要再次手术的高发生率,我们不建议对这种适应症采用这种手术策略。

证据等级

4 级。

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