Cudney S M, Vieira A R
Department of Oral Biology, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA 15261, USA.
Eur Arch Paediatr Dent. 2012 Dec;13(6):297-304. doi: 10.1007/BF03320830.
This review discusses the complex epithelial-mesenchymal interactions that occur during tooth development and systemic anomalies that may result in hypodontia. Emphasis is placed on four interacting signaling families (Shh, FGF, BMP, and Wnt) that have been identified for their integral role in complete tooth development and on several genetic mutations in the MSX1, PAX9, EDA, and AXIN2 genes that arrest tooth development. Proposed treatment options are presented, including signaling factor supplementation and stem cell isolation for bioengineering new teeth.
本综述讨论了牙齿发育过程中发生的复杂上皮-间充质相互作用以及可能导致牙齿发育不全的全身异常情况。重点关注四个相互作用的信号家族（Shh、FGF、BMP和Wnt），它们已被确定在完整牙齿发育中起不可或缺的作用，还关注MSX1、PAX9、EDA和AXIN2基因中的几种基因突变，这些突变会阻碍牙齿发育。文中还提出了建议的治疗方案，包括补充信号因子和分离干细胞以进行生物工程制造新牙齿。
