Nikishov V N, Bogdanov E I, Sanadze A G, Sigal E I, Sidnev D V, Dedaev S I, Kondrat'ev A V
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(9):32-6.
Thymectomy and removal of the hyperplastic thymus have been performed in 21 patients with myasthenia. In 14 patients, thymectomy is performed through thoracoscopic access (TA), while in 7 cases through thoracotomic access (TT). The serum levels of antibodies to acetylcholine receptors (AChR) determined before and after surgery were increased in both groups of patients. Thus, thymectomy, regardless of the degree of clinical improvement in early post operative period, significantly increases the level of anti-AChR antibodies in the serum of patients in the early postoperative period compared to baseline. These changes may reflect the immune response to a stressful situation related to the traumatic surgery. It should be noted that the level of anti-AChR antibodies was significantly higher in a group of TT that may be related with a larger volume of the removed tissue.
对21例重症肌无力患者实施了胸腺切除术及增生胸腺切除术。14例患者通过胸腔镜入路（TA）进行胸腺切除术，7例通过开胸入路（TT）进行。两组患者术前和术后测定的血清乙酰胆碱受体（AChR）抗体水平均升高。因此，胸腺切除术无论术后早期临床改善程度如何，与基线相比，术后早期患者血清中抗AChR抗体水平均显著升高。这些变化可能反映了对与创伤性手术相关的应激情况的免疫反应。应当指出，TT组的抗AChR抗体水平显著更高，这可能与切除组织量较大有关。
