重症肌无力患者胸腺切除术后抗乙酰胆碱受体抗体的长期变化

Long-term change of anti-acetylcholine receptor antibody in patients with myasthenia gravis after thymectomy.

作者信息

Hayashi M, Manabe K, Takaoka T, Yamada I, Kida K, Matsuda H, Yoshinaga J

机构信息

Department of Pediatrics, Ehime University School of Medicine, Japan.

出版信息

Acta Paediatr Jpn. 1995 Jun;37(3):362-6. doi: 10.1111/j.1442-200x.1995.tb03331.x.

DOI:10.1111/j.1442-200x.1995.tb03331.x

PMID:7645389

Abstract

Anti-acetylcholine receptor antibody (AChR Ab) plays an important role in the pathogenesis of myasthenia gravis (MG). We investigated the change of anti-AChR Ab titer after thymectomy of 10 MG patients including five patients whose age at onset was younger than 16 years. Anti-AChR Ab titer was increased in four of six patients with remission and three of four patients without remission. Change of anti-AChR Ab titer in individual patients showed an increase occurred 1-4 years after thymectomy. It is likely that thymectomy influences immune response and induces autoreactive lymphocytes and autoantibodies.

摘要

抗乙酰胆碱受体抗体（AChR Ab）在重症肌无力（MG）的发病机制中起重要作用。我们研究了10例MG患者胸腺切除术后抗AChR Ab滴度的变化，其中包括5例发病年龄小于16岁的患者。6例缓解患者中有4例抗AChR Ab滴度升高，4例未缓解患者中有3例升高。个别患者抗AChR Ab滴度的变化显示在胸腺切除术后1 - 4年出现升高。胸腺切除术可能影响免疫反应并诱导自身反应性淋巴细胞和自身抗体。