The maintenance of epigenetic states by p53: the guardian of the epigenome.
作者信息
Levine Arnold J, Greenbaum Benjamin
机构信息
Institute for Advanced Study, Einstein Road, Princeton, NJ, USA.
出版信息
Oncotarget. 2012 Dec;3(12):1503-4. doi: 10.18632/oncotarget.780.
Abstract
摘要
相似文献
1
The maintenance of epigenetic states by p53: the guardian of the epigenome.p53对表观遗传状态的维持：表观基因组的守护者。
Oncotarget. 2012 Dec;3(12):1503-4. doi: 10.18632/oncotarget.780.
2
p53: master of life, death, and the epigenome.p53：生命、死亡与表观基因组的主宰者。
Genes Dev. 2017 May 15;31(10):955-956. doi: 10.1101/gad.302364.117.
3
Elaborate security TRAINing to fight against expression of genomic junk.精心设计的安全培训，以对抗基因组垃圾的表达。
Cell Cycle. 2013 Feb 15;12(4):553-4. doi: 10.4161/cc.23717. Epub 2013 Jan 31.
4
p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.p53 与 DNA 甲基化和自杀性干扰素反应合作，维持重复序列和非编码 RNA 的表观遗传沉默。
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E89-98. doi: 10.1073/pnas.1216922110. Epub 2012 Dec 10.
5
The Impact of Mutant p53 in the Non-Coding RNA World.突变型 p53 在非编码 RNA 世界中的影响。
Biomolecules. 2020 Mar 19;10(3):472. doi: 10.3390/biom10030472.
6
SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer.SOX30是一种新型的表观遗传沉默的肿瘤抑制因子，它通过转录激活肺癌中的p53来促进肿瘤细胞凋亡。
Oncogene. 2015 Aug 13;34(33):4391-402. doi: 10.1038/onc.2014.370. Epub 2014 Dec 1.
7
Interplay between regulation by methylation and noncoding RNAs in cancers.癌症中甲基化调控与非编码RNA之间的相互作用。
Eur J Cancer Prev. 2018 Jul;27(4):418-424. doi: 10.1097/CEJ.0000000000000433.
8
Epigenetic regulation by DNA methylation and miRNA molecules in cancer.DNA甲基化和微小RNA分子在癌症中的表观遗传调控
Future Oncol. 2017 Oct;13(25):2217-2222. doi: 10.2217/fon-2017-0363. Epub 2017 Oct 4.
9
Molecular biology. Genetic events that shape the cancer epigenome.分子生物学。塑造癌症表观基因组的遗传事件。
Science. 2012 Jun 22;336(6088):1513-4. doi: 10.1126/science.1223730.
10
Transcriptional and epigenetic regulation of the p53 tumor suppressor gene.p53 肿瘤抑制基因的转录和表观遗传调控。
Epigenetics. 2011 Sep 1;6(9):1068-77. doi: 10.4161/epi.6.9.16683.
引用本文的文献
1
Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?解码p53的肿瘤抑制作用：基因组稳定性与表观遗传控制之间的相互作用？
Cell Death Differ. 2025 Jan;32(1):1-8. doi: 10.1038/s41418-024-01259-9. Epub 2024 Feb 20.
2
Non-Random Selection of Cancer-Causing Mutations in Tissue-Specific Stem Cells Cause Cancer.组织特异性干细胞中致癌突变的非随机选择导致癌症。
J Clin Oncol Res. 2020;8(1). Epub 2020 Sep 22.
3
Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia.5-羟甲基胞嘧啶下调与宫颈上皮内瘤变的进展有关。
PLoS One. 2020 Nov 3;15(11):e0241482. doi: 10.1371/journal.pone.0241482. eCollection 2020.
4
p53: 800 million years of evolution and 40 years of discovery.p53：8 亿年的进化与 40 年的发现。
Nat Rev Cancer. 2020 Aug;20(8):471-480. doi: 10.1038/s41568-020-0262-1. Epub 2020 May 13.
5
Epimutation and Cancer: Carcinogenesis Viewed as Error-Prone Inheritance of Epigenetic Information.表观突变与癌症：将致癌作用视为表观遗传信息的易出错遗传
J Oncol. 2018 Jun 3;2018:2645095. doi: 10.1155/2018/2645095. eCollection 2018.
6
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.增强子重编程促进胰腺癌转移。
Cell. 2017 Aug 24;170(5):875-888.e20. doi: 10.1016/j.cell.2017.07.007. Epub 2017 Jul 27.
7
Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.细胞状态可塑性、干细胞、上皮-间质转化与肿瘤内异质性的产生
NPJ Breast Cancer. 2017 Apr 19;3:14. doi: 10.1038/s41523-017-0012-z. eCollection 2017.
8
p53: master of life, death, and the epigenome.p53：生命、死亡与表观基因组的主宰者。
Genes Dev. 2017 May 15;31(10):955-956. doi: 10.1101/gad.302364.117.
9
p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity.p53对于原始胚胎干细胞中的DNA甲基化稳态至关重要，其缺失会促进克隆异质性。
Genes Dev. 2017 May 15;31(10):959-972. doi: 10.1101/gad.299198.117. Epub 2017 Jun 12.
10
P53 and the defenses against genome instability caused by transposons and repetitive elements.P53与针对转座子和重复元件所导致的基因组不稳定的防御机制。
Bioessays. 2016 Jun;38(6):508-13. doi: 10.1002/bies.201600031. Epub 2016 May 13.
本文引用的文献
1
p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.p53 与 DNA 甲基化和自杀性干扰素反应合作，维持重复序列和非编码 RNA 的表观遗传沉默。
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E89-98. doi: 10.1073/pnas.1216922110. Epub 2012 Dec 10.
2
The interfaces between signal transduction pathways: IGF-1/mTor, p53 and the Parkinson Disease pathway.信号转导通路之间的界面：胰岛素样生长因子-1/雷帕霉素靶蛋白、p53与帕金森病通路。
Oncotarget. 2012 Nov;3(11):1301-7. doi: 10.18632/oncotarget.759.
3
Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation.p53 相关通路在体细胞重编程和干细胞分化中的多重作用。
Cancer Res. 2012 Nov 1;72(21):5635-45. doi: 10.1158/0008-5472.CAN-12-1451. Epub 2012 Sep 10.
4
Molecular classification of prostate cancer using curated expression signatures.基于经整理的表达特征对前列腺癌进行分子分类。
Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21276-81. doi: 10.1073/pnas.1117029108. Epub 2011 Nov 28.
5
Oligonucleotide motifs that disappear during the evolution of influenza virus in humans increase alpha interferon secretion by plasmacytoid dendritic cells.在人类流感病毒进化过程中消失的寡核苷酸基序会增加浆细胞样树突状细胞分泌的α干扰素。
J Virol. 2011 Apr;85(8):3893-904. doi: 10.1128/JVI.01908-10. Epub 2011 Feb 9.
6
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.卫星重复序列在胰腺和其他上皮性癌症中的异常过表达。
Science. 2011 Feb 4;331(6017):593-6. doi: 10.1126/science.1200801. Epub 2011 Jan 13.
7
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.乳腺癌中 p53 的失活与干细胞转录特征相关。
Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22745-50. doi: 10.1073/pnas.1017001108. Epub 2010 Dec 13.
8
Stem cell biology meets p53.干细胞生物学与p53相遇。
Nat Biotechnol. 2009 Oct;27(10):914-5. doi: 10.1038/nbt1009-914.
9
Patterns of oligonucleotide sequences in viral and host cell RNA identify mediators of the host innate immune system.病毒和宿主细胞RNA中的寡核苷酸序列模式可识别宿主先天免疫系统的介质。
PLoS One. 2009 Jun 18;4(6):e5969. doi: 10.1371/journal.pone.0005969.
10
Patterns of evolution and host gene mimicry in influenza and other RNA viruses.流感及其他RNA病毒的进化模式与宿主基因模拟
PLoS Pathog. 2008 Jun 6;4(6):e1000079. doi: 10.1371/journal.ppat.1000079.
Zotero 插件