IRCCS Regina Elena National Cancer Institute-IFO, Oncogenomic and Epigenetic Unit; via Elio Chianesi, 53-00144 Rome, Italy.
Biomolecules. 2020 Mar 19;10(3):472. doi: 10.3390/biom10030472.
Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), micro RNAs (miRNAs), and extracellular RNAs (exRNAs) are new groups of RNAs with regulation activities that have low or no protein-coding ability. Emerging evidence suggests that deregulated expression of these non-coding RNAs is associated with the induction and progression of diverse tumors throughout epigenetic, transcriptional, and post-transcriptional modifications. A consistent number of non-coding RNAs (ncRNAs) has been shown to be regulated by p53, the most important tumor suppressor of the cells frequently mutated in human cancer. It has been shown that some mutant p53 proteins are associated with the loss of tumor suppressor activity and the acquisition of new oncogenic functions named gain-of-function activities. In this review, we highlight recent lines of evidence suggesting that mutant p53 is involved in the expression of specific ncRNAs to gain oncogenic functions through the creation of a complex network of pathways that influence each other.
长链非编码 RNA（lncRNA）、环状 RNA（circRNA）、微小 RNA（miRNA）和细胞外 RNA（exRNA）是一组新的具有调控活性的 RNA，其蛋白编码能力较低或没有。新出现的证据表明，这些非编码 RNA 的表达失调与各种肿瘤的诱导和进展有关，涉及表观遗传、转录和转录后修饰。大量的非编码 RNA（ncRNA）被证明受到 p53 的调控，p53 是人类癌症中经常发生突变的细胞中最重要的肿瘤抑制因子。已经表明，一些突变型 p53 蛋白与肿瘤抑制活性的丧失和获得新的致癌功能（称为获得性功能）有关。在这篇综述中，我们强调了最近的证据表明，突变型 p53 参与特定 ncRNA 的表达，通过创建相互影响的复杂通路网络获得致癌功能。
