Lee Jonathan L C
School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Trends Neurosci. 2009 Aug;32(8):413-20. doi: 10.1016/j.tins.2009.05.002. Epub 2009 Jul 27.
The retrieval of a memory places it into a plastic state, the result of which is that the memory can be disrupted or even enhanced by experimental treatment. This phenomenon has been conceptualised within a framework of memories being reactivated and then reconsolidated in repeated rounds of cellular processing. The reconsolidation phase has been seized upon as crucial for the understanding of memory stability and, more recently, as a potential therapeutic target in the treatment of disorders such as post-traumatic stress and drug addiction. However, little is known about the reactivation process, or what might be the adaptive function of retrieval-induced plasticity. Reconsolidation has long been proposed to mediate memory updating, but only recently has this hypothesis been supported experimentally. Here, the adaptive function of memory reconsolidation is explored in more detail, with a strong emphasis on its role in updating memories to maintain their relevance.
记忆的提取会使其进入一种可塑性状态，其结果是该记忆可能会受到实验性处理的干扰甚至增强。这种现象已在一个记忆被重新激活然后在反复的细胞处理过程中重新巩固的框架内被概念化。重新巩固阶段被认为对于理解记忆稳定性至关重要，并且最近被视为治疗创伤后应激障碍和药物成瘾等疾病的潜在治疗靶点。然而，对于重新激活过程，或者提取诱导可塑性的适应性功能可能是什么，人们知之甚少。长期以来，人们一直认为重新巩固介导记忆更新，但直到最近这一假设才得到实验支持。在这里，我们更详细地探讨了记忆重新巩固的适应性功能，特别强调了它在更新记忆以保持其相关性方面的作用。
