Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
PLoS One. 2012;7(12):e51788. doi: 10.1371/journal.pone.0051788. Epub 2012 Dec 11.
In this study, we present pituitary adenoma volumetry using the free and open source medical image computing platform for biomedical research: (3D) Slicer. Volumetric changes in cerebral pathologies like pituitary adenomas are a critical factor in treatment decisions by physicians and in general the volume is acquired manually. Therefore, manual slice-by-slice segmentations in magnetic resonance imaging (MRI) data, which have been obtained at regular intervals, are performed. In contrast to this manual time consuming slice-by-slice segmentation process Slicer is an alternative which can be significantly faster and less user intensive. In this contribution, we compare pure manual segmentations of ten pituitary adenomas with semi-automatic segmentations under Slicer. Thus, physicians drew the boundaries completely manually on a slice-by-slice basis and performed a Slicer-enhanced segmentation using the competitive region-growing based module of Slicer named GrowCut. Results showed that the time and user effort required for GrowCut-based segmentations were on average about thirty percent less than the pure manual segmentations. Furthermore, we calculated the Dice Similarity Coefficient (DSC) between the manual and the Slicer-based segmentations to proof that the two are comparable yielding an average DSC of 81.97±3.39%.
在这项研究中,我们使用免费和开源的医学图像计算平台(3D Slicer)展示了垂体腺瘤的体积测量。脑病变(如垂体腺瘤)的体积变化是医生治疗决策的关键因素,通常需要手动获取体积。因此,需要对定期获取的磁共振成像(MRI)数据进行手动逐层分割。与这种耗时的手动逐层分割过程相比,Slicer 是一种替代方法,它可以显著更快且用户负担更小。在本研究中,我们将十例垂体腺瘤的纯手动分割与 Slicer 下的半自动分割进行了比较。因此,医生在逐层的基础上完全手动绘制边界,并使用 Slicer 中名为 GrowCut 的基于竞争区域增长的模块进行 Slicer 增强分割。结果表明,基于 GrowCut 的分割所需的时间和用户工作量平均比纯手动分割少约 30%。此外,我们计算了手动和基于 Slicer 的分割之间的 Dice 相似性系数(DSC),以证明两者是可比的,平均 DSC 为 81.97±3.39%。
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