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Converging on a mechanism for choline degradation.

作者信息

Thibodeaux Christopher J, van der Donk Wilfred A

机构信息

Institute for Genomic Biology, University of Illinois, Urbana, IL 61801, USA.

出版信息

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21184-5. doi: 10.1073/pnas.1219534110. Epub 2012 Dec 14.

DOI:10.1073/pnas.1219534110
PMID:23243142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3535664/
Abstract
摘要

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本文引用的文献

1
Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme.胆碱向三甲胺的微生物转化需要甘氨酰基自由基酶。
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21307-12. doi: 10.1073/pnas.1215689109. Epub 2012 Nov 14.
2
Glycerol dehydratation by the B12-independent enzyme may not involve the migration of a hydroxyl group: a computational study.B12 非依赖型酶的甘油脱水作用可能不涉及羟基迁移：一项计算研究。
J Phys Chem B. 2012 Jun 21;116(24):7076-87. doi: 10.1021/jp301165b. Epub 2012 Jun 8.
3
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.肠道菌群对磷脂酰胆碱的代谢作用促进了心血管疾病的发生。
Nature. 2011 Apr 7;472(7341):57-63. doi: 10.1038/nature09922.
4
Crystal structures of ethanolamine ammonia-lyase complexed with coenzyme B12 analogs and substrates.乙醇胺氨裂解酶与辅酶 B12 类似物和底物复合物的晶体结构。
J Biol Chem. 2010 Aug 20;285(34):26484-93. doi: 10.1074/jbc.M110.125112. Epub 2010 Jun 1.
5
Ethanolamine utilization in bacterial pathogens: roles and regulation.乙醇胺在细菌病原体中的利用：作用与调控。
Nat Rev Microbiol. 2010 Apr;8(4):290-5. doi: 10.1038/nrmicro2334.
6
Modeling the reactions catalyzed by coenzyme B12-dependent enzymes.模拟钴胺素 B12 依赖性酶催化的反应。
Acc Chem Res. 2010 May 18;43(5):642-51. doi: 10.1021/ar900260c.
7
Choline: an essential nutrient for public health.胆碱：公共健康的必需营养素。
Nutr Rev. 2009 Nov;67(11):615-23. doi: 10.1111/j.1753-4887.2009.00246.x.
8
Identification of the substrate radical intermediate derived from ethanolamine during catalysis by ethanolamine ammonia-lyase.乙醇胺氨裂合酶催化过程中源自乙醇胺的底物自由基中间体的鉴定。
Biochemistry. 2008 Oct 28;47(43):11360-6. doi: 10.1021/bi801316v. Epub 2008 Oct 1.
9
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.代谢谱分析揭示肠道微生物群对胰岛素抵抗小鼠脂肪肝表型的影响。
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12511-6. doi: 10.1073/pnas.0601056103. Epub 2006 Aug 8.
10
Radical enzymes in anaerobes.厌氧菌中的自由基酶。
Annu Rev Microbiol. 2006;60:27-49. doi: 10.1146/annurev.micro.60.080805.142216.