Department of Biology, University of Dayton, Dayton, OH 45469-2320, USA.
Hum Genomics. 2012 Aug 2;6(1):10. doi: 10.1186/1479-7364-6-10.
In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence.
在这篇综述中，我们研究了在不相关或非同源蛋白质中蛋白质结构基序保守的例子。为此，我们选择了三个 DNA 结合基序：组蛋白折叠、螺旋-转角-螺旋基序和锌指以及球蛋白样折叠。我们表明，在不相关的蛋白质中确实存在类似的结构，这加强了三维保守性可能比一级氨基酸序列更重要的概念。
