年轻成年人中的脂质过氧化物、谷胱甘肽过氧化物酶、高密度脂蛋白亚组分及载脂蛋白

Lipid peroxides, glutathione peroxidase, high density lipoprotein subfractions and apolipoproteins in young adults.

作者信息

Luoma P V, Stengård J, Korpela H, Rautio A, Sotaniemi E A, Suvanto E, Marniemi J

机构信息

Department of Medicine, University of Oulu, Finland.

出版信息

J Intern Med. 1990 Apr;227(4):287-9. doi: 10.1111/j.1365-2796.1990.tb00161.x.

DOI:10.1111/j.1365-2796.1990.tb00161.x

PMID:2324684

Abstract

Lipid peroxides have been implicated in the initiation of atherogenesis. In this study of 23 young healthy subjects, high levels of serum lipid peroxides were associated with low serum HDL2 cholesterol concentrations and low HDL2/HDL3 cholesterol and apolipoprotein A-I/A-II ratios. Low levels of LDL cholesterol and apolipoprotein B, and low apolipoprotein B/A-I ratios were typical of subjects with high serum glutathione peroxidase activities. Serum lipid peroxide levels varied widely in subjects without abnormal cholesterol, HDL cholesterol or LDL cholesterol concentrations. This variation may play a role in the frequent occurrence of coronary artery disease in normolipidaemic individuals.

摘要

脂质过氧化物与动脉粥样硬化的起始有关。在这项针对23名年轻健康受试者的研究中，血清脂质过氧化物水平升高与血清高密度脂蛋白2（HDL2）胆固醇浓度降低、HDL2/HDL3胆固醇比值及载脂蛋白A-I/A-II比值降低相关。血清谷胱甘肽过氧化物酶活性高的受试者典型特征为低密度脂蛋白（LDL）胆固醇和载脂蛋白B水平低，以及载脂蛋白B/A-I比值低。在胆固醇、HDL胆固醇或LDL胆固醇浓度无异常的受试者中，血清脂质过氧化物水平差异很大。这种差异可能在血脂正常个体中冠心病的频繁发生中起作用。