低氧血症时犬骨骼肌毛细血管血流和氧气供应的调节
Regulation of capillary blood flow and oxygen supply in skeletal muscle in dogs during hypoxaemia.
作者信息
Harrison D K, Kessler M, Knauf S K
机构信息
Institut für Physiologie und Kardiologie, University of Erlangen/Nürnberg, FRG.
出版信息
J Physiol. 1990 Jan;420:431-46. doi: 10.1113/jphysiol.1990.sp017921.
Abstract
- Multiwire surface electrodes were used to measure local hydrogen clearance curves and tissue PO2 in vivo. Evaluation of the initial slopes of the hydrogen clearance curves enabled the measurement of capillary blood flow and its distribution. 2. Capillary blood flow and tissue PO2 frequency distribution histograms were measured in the m. sartorius of anaesthetized, relaxed mongrel dogs under conditions of normoxic (Fi, O2 = 0.3) and hypoxic (Fi, O2 = 0.15 and 0.1) artificial ventilation. 3. Stepwise hypoxaemia (hypoxic hypoxia) induced an increasing discrepancy between capillary blood flow and arterial blood flow. The former decreased by 6% whereas the latter increased by 86%. 4. PO2 histograms provided no evidence of cellular anoxia even at Fi,O2 = 0.1. Capillary blood flow histograms suggested a redistribution of the local pattern of flow. 5. A 34.7% reduction of O2 consumption was observed as the result of severe hypoxaemia. 6. The concept of heterogeneity of capillary blood flow as a functional O2 reserve is presented, together with evidence for oxygen-dependent regulation of capillary blood flow and oxygen consumption.
摘要
- 使用多丝表面电极在体内测量局部氢清除曲线和组织氧分压。对氢清除曲线初始斜率的评估能够测量毛细血管血流量及其分布。2. 在常氧（吸入氧分数Fi,O2 = 0.3）和低氧（Fi,O2 = 0.15和0.1）人工通气条件下，在麻醉、放松的杂种犬的缝匠肌中测量毛细血管血流量和组织氧分压频率分布直方图。3. 逐步低氧血症（低张性缺氧）导致毛细血管血流量与动脉血流量之间的差异增大。前者下降了6%，而后者增加了86%。4. 即使在Fi,O2 = 0.1时，氧分压直方图也未提供细胞缺氧的证据。毛细血管血流量直方图表明局部血流模式发生了重新分布。5. 严重低氧血症导致氧耗量降低了34.7%。6. 提出了毛细血管血流异质性作为功能性氧储备的概念，以及毛细血管血流和氧耗量的氧依赖性调节的证据。
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