在大鼠基因组数据库中探索遗传、基因组和表型数据。
Exploring genetic, genomic, and phenotypic data at the rat genome database.
作者信息
Laulederkind Stanley J F, Hayman G Thomas, Wang Shur-Jen, Lowry Timothy F, Nigam Rajni, Petri Victoria, Smith Jennifer R, Dwinell Melinda R, Jacob Howard J, Shimoyama Mary
机构信息
Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
出版信息
Curr Protoc Bioinformatics. 2012 Dec;Chapter 1:1.14.1-1.14.27. doi: 10.1002/0471250953.bi0114s40.
The laboratory rat, Rattus norvegicus, is an important model of human health and disease, and experimental findings in the rat have relevance to human physiology and disease. The Rat Genome Database (RGD, http://rgd.mcw.edu) is a model organism database that provides access to a wide variety of curated rat data including disease associations, phenotypes, pathways, molecular functions, biological processes, and cellular components for genes, quantitative trait loci, and strains. We present an overview of the database followed by specific examples that can be used to gain experience in employing RGD to explore the wealth of functional data available for the rat.
实验大鼠褐家鼠是人类健康与疾病的重要模型，在大鼠身上的实验结果与人类生理学和疾病相关。大鼠基因组数据库（RGD，http://rgd.mcw.edu）是一个模式生物数据库，可提供广泛的经过整理的大鼠数据，包括疾病关联、表型、通路、分子功能、生物过程以及基因、数量性状基因座和品系的细胞成分等信息。我们先对该数据库进行概述，然后给出具体示例，这些示例可用于积累利用RGD探索大鼠可用功能数据的经验。
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