Human and Molecular Genetics Center, Medical College of Wisconsin, Human and Molecular Genetics Center, 8701 Watertown Plank Rd, Milwaukee, WI 53226-3548, USA.
Database (Oxford). 2013 Apr 19;2013:bat015. doi: 10.1093/database/bat015. Print 2013.
The Rat Genome Database (RGD) is the premier repository of rat genomic and genetic data and currently houses >40 000 rat gene records as well as human and mouse orthologs, >2000 rat and 1900 human quantitative trait loci (QTLs) records and >2900 rat strain records. Biological information curated for these data objects includes disease associations, phenotypes, pathways, molecular functions, biological processes and cellular components. Recently, a project was initiated at RGD to incorporate quantitative phenotype data for rat strains, in addition to the currently existing qualitative phenotype data for rat strains, QTLs and genes. A specialized curation tool was designed to generate manual annotations with up to six different ontologies/vocabularies used simultaneously to describe a single experimental value from the literature. Concurrently, three of those ontologies needed extensive addition of new terms to move the curation forward. The curation interface development, as well as ontology development, was an ongoing process during the early stages of the PhenoMiner curation project. Database URL: http://rgd.mcw.edu.
大鼠基因组数据库（RGD）是大鼠基因组和遗传数据的主要存储库，目前拥有超过 40000 个大鼠基因记录，以及人类和小鼠的同源基因、超过 2000 个大鼠和 1900 个人类数量性状位点（QTL）记录和超过 2900 个大鼠品系记录。为这些数据对象精心编制的生物学信息包括疾病关联、表型、途径、分子功能、生物学过程和细胞成分。最近，RGD 启动了一个项目，除了现有的大鼠品系、QTL 和基因的定性表型数据外，还将纳入大鼠品系的定量表型数据。专门设计了一个编校工具，用于生成多达六个不同本体/词汇的手动注释，同时描述文献中的单个实验值。同时，为了推进编校工作，其中三个本体需要大量添加新术语。在 PhenoMiner 编校项目的早期阶段，编校界面开发以及本体开发是一个持续的过程。数据库网址：http://rgd.mcw.edu。
