Haque Ashanul, Faizi Md Serajul Haque, Rather Jahangir Ahmad, Khan Muhammad S
Department of Chemistry, College of Sciences, Sultan Qaboos University, Muscat, Oman.
Department of Chemistry, College of Sciences, Sultan Qaboos University, Muscat, Oman.
Bioorg Med Chem. 2017 Apr 1;25(7):2017-2034. doi: 10.1016/j.bmc.2017.02.061. Epub 2017 Feb 28.
Cancer is a group of diseases responsible for the major causes of mortality and morbidity among people of all ages. Even though medical sciences have made enormous growth, complete treatment of this deadly disease is still a challenging task. Last few decades witnessed an impressive growth in the design and development of near infrared (NIR) fluorophores with and without recognition moieties for molecular recognitions, imaging and image guided surgeries. The present article reviews recently reported NIR emitting organic/inorganic fluorophores that targets and accumulates in organelle/organs specifically for molecular imaging of cancerous cells. Near infrared (NIR probe) with or without a tumor-targeting warhead have been considered and discussed for their applications in the field of cancer imaging. In addition, challenges persist in this area are also delineated in this review.
癌症是一组导致各年龄段人群死亡和发病的主要原因的疾病。尽管医学科学取得了巨大进展，但彻底治疗这种致命疾病仍然是一项具有挑战性的任务。在过去几十年中，用于分子识别、成像和图像引导手术的带有或不带有识别基团的近红外（NIR）荧光团的设计和开发取得了令人瞩目的进展。本文综述了最近报道的近红外发射有机/无机荧光团，这些荧光团专门靶向并聚集在细胞器/器官中，用于癌细胞的分子成像。本文考虑并讨论了带有或不带有肿瘤靶向弹头的近红外（NIR探针）在癌症成像领域的应用。此外，本综述还阐述了该领域仍然存在的挑战。
