Gurulingappa Harsha, Mateen-Rajput Abdul, Toldo Luca
, Merck KGaA, Frankfurterstraße 250, Darmstadt 64293, Germany.
J Biomed Semantics. 2012 Dec 20;3(1):15. doi: 10.1186/2041-1480-3-15.
: The sheer amount of information about potential adverse drug events published in medical case reports pose major challenges for drug safety experts to perform timely monitoring. Efficient strategies for identification and extraction of information about potential adverse drug events from free-text resources are needed to support pharmacovigilance research and pharmaceutical decision making. Therefore, this work focusses on the adaptation of a machine learning-based system for the identification and extraction of potential adverse drug event relations from MEDLINE case reports. It relies on a high quality corpus that was manually annotated using an ontology-driven methodology. Qualitative evaluation of the system showed robust results. An experiment with large scale relation extraction from MEDLINE delivered under-identified potential adverse drug events not reported in drug monographs. Overall, this approach provides a scalable auto-assistance platform for drug safety professionals to automatically collect potential adverse drug events communicated as free-text data.
医学病例报告中发表的关于潜在药物不良事件的信息量巨大,给药物安全专家进行及时监测带来了重大挑战。需要有效的策略从自由文本资源中识别和提取有关潜在药物不良事件的信息,以支持药物警戒研究和制药决策。因此,这项工作专注于改编一个基于机器学习的系统,用于从MEDLINE病例报告中识别和提取潜在药物不良事件关系。它依赖于使用本体驱动方法进行手动注释的高质量语料库。对该系统的定性评估显示了稳健的结果。一项从MEDLINE进行大规模关系提取的实验发现了药品说明书中未报告的潜在药物不良事件识别不足的情况。总体而言,这种方法为药物安全专业人员提供了一个可扩展的自动辅助平台,以自动收集作为自由文本数据传达的潜在药物不良事件。