气相离子/离子反应的肽和蛋白质：酸碱、氧化还原和共价化学。
Gas-phase ion/ion reactions of peptides and proteins: acid/base, redox, and covalent chemistries.
机构信息
Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN 47907-2084, USA.
出版信息
Chem Commun (Camb). 2013 Feb 1;49(10):947-65. doi: 10.1039/c2cc36577d. Epub 2012 Dec 20.
Abstract
Gas-phase ion/ion reactions are emerging as useful and flexible means for the manipulation and characterization of peptide and protein biopolymers. Acid/base-like chemical reactions (i.e., proton transfer reactions) and reduction/oxidation (redox) reactions (i.e., electron transfer reactions) represent relatively mature classes of gas-phase chemical reactions. Even so, especially in regards to redox chemistry, the widespread utility of these two types of chemistries is undergoing rapid growth and development. Additionally, a relatively new class of gas-phase ion/ion transformations is emerging which involves the selective formation of functional-group-specific covalent bonds. This feature details our current work and perspective on the developments and current capabilities of these three areas of ion/ion chemistry with an eye towards possible future directions of the field.
摘要
气相离子/离子反应正成为一种有用且灵活的手段，可用于操纵和表征肽和蛋白质生物聚合物。酸/碱样化学反应（即质子转移反应）和还原/氧化（氧化还原）反应（即电子转移反应）代表了相对成熟的气相化学反应类别。即便如此，特别是在氧化还原化学方面，这两种类型的化学物质的广泛应用正在迅速发展和壮大。此外，一种新的气相离子/离子转化类型正在出现，涉及到特定官能团共价键的选择性形成。本文详细介绍了我们目前在离子/离子化学这三个领域的工作和观点，以及该领域未来可能的发展方向。
相似文献
1
Gas-phase ion/ion reactions of peptides and proteins: acid/base, redox, and covalent chemistries.气相离子/离子反应的肽和蛋白质：酸碱、氧化还原和共价化学。
Chem Commun (Camb). 2013 Feb 1;49(10):947-65. doi: 10.1039/c2cc36577d. Epub 2012 Dec 20.
2
Selective Gas-Phase Ion/Ion Reactions: Enabling Disulfide Mapping via Oxidation and Cleavage of Disulfide Bonds in Intermolecularly-Linked Polypeptide Ions.选择性气相离子/离子反应：通过氧化和断裂分子间连接的多肽离子中的二硫键实现二硫键图谱绘制。
Anal Chem. 2016 Sep 20;88(18):8972-9. doi: 10.1021/acs.analchem.6b01043. Epub 2016 Aug 29.
3
Electron transfer versus proton transfer in gas-phase ion/ion reactions of polyprotonated peptides.多质子化肽的气相离子/离子反应中的电子转移与质子转移
J Am Chem Soc. 2005 Sep 14;127(36):12627-39. doi: 10.1021/ja0526057.
4
Planning Implications Related to Sterilization-Sensitive Science Investigations Associated with Mars Sample Return (MSR).与火星样本返回（MSR）相关的对灭菌敏感的科学研究的规划意义。
Astrobiology. 2022 Jun;22(S1):S112-S164. doi: 10.1089/AST.2021.0113. Epub 2022 May 19.
5
Gas-phase chemistry of multiply charged bioions in analytical mass spectrometry.分析质谱中多电荷生物离子的气相化学。
Annu Rev Anal Chem (Palo Alto Calif). 2010;3:365-85. doi: 10.1146/annurev.anchem.111808.073725.
6
Oxidation of methionine residues in polypeptide ions via gas-phase ion/ion chemistry.通过气相离子/离子化学对多肽离子中甲硫氨酸残基进行氧化
J Am Soc Mass Spectrom. 2014 Jun;25(6):1049-57. doi: 10.1007/s13361-014-0861-8. Epub 2014 Mar 27.
7
Ion-molecule reactions as probes of gas-phase structures of peptides and proteins.离子-分子反应作为肽和蛋白质气相结构的探针。
Mass Spectrom Rev. 1997 Mar-Apr;16(2):53-71. doi: 10.1002/(SICI)1098-2787(1997)16:2<53::AID-MAS1>3.0.CO;2-8.
8
Selective Gas-Phase Oxidation and Localization of Alkylated Cysteine Residues in Polypeptide Ions via Ion/Ion Chemistry.通过离子/离子化学实现多肽离子中烷基化半胱氨酸残基的选择性气相氧化和定位
J Proteome Res. 2016 Sep 2;15(9):3139-46. doi: 10.1021/acs.jproteome.6b00266. Epub 2016 Aug 18.
9
Visible and ultraviolet spectroscopy of gas phase protein ions.气相蛋白离子的可见和紫外光谱。
Phys Chem Chem Phys. 2011 Oct 6;13(37):16494-509. doi: 10.1039/c1cp21531k. Epub 2011 Aug 2.
10
Gas-phase proton-transfer chemistry coupled with TOF mass spectrometry and ion mobility-MS for the facile analysis of poly(ethylene glycols) and PEGylated polypeptide conjugates.气相质子转移化学与飞行时间质谱和离子淌度质谱联用，用于聚乙二醇及聚乙二醇化多肽偶联物的简便分析。
Anal Chem. 2008 Apr 1;80(7):2408-18. doi: 10.1021/ac7020163. Epub 2008 Mar 7.
引用本文的文献
1
An Analytical Evaluation of Tools for Lipid Isomer Differentiation in Imaging Mass Spectrometry.成像质谱中脂质异构体区分工具的分析评估
Int J Mass Spectrom. 2024 Aug;502. doi: 10.1016/j.ijms.2024.117268. Epub 2024 May 26.
2
Imaging Mass Spectrometry of Sulfatide Isomers from Rat Brain Tissue Using Gas-Phase Charge Inversion Ion/Ion Reactions.利用气相电荷反转离子/离子反应对大鼠脑组织中硫苷脂异构体进行成像质谱分析。
J Am Soc Mass Spectrom. 2025 Jan 1;36(1):119-126. doi: 10.1021/jasms.4c00368. Epub 2024 Nov 25.
3
Evidence of Gas Phase Glucosyl Transfer and Glycation in the CID/HCD-Spectra of S-Glucosylated Peptides.在 CID/HCD 谱中 S-糖基化肽的气相糖基转移和糖化的证据。
Int J Mol Sci. 2024 Jul 8;25(13):7483. doi: 10.3390/ijms25137483.
4
Enhancing Spatial Resolution in Tandem Mass Spectrometry Ion/Ion Reaction Imaging Experiments through Image Fusion.通过图像融合提高串联质谱离子/离子反应成像实验的空间分辨率。
J Am Soc Mass Spectrom. 2024 Aug 7;35(8):1797-1805. doi: 10.1021/jasms.4c00144. Epub 2024 Jul 2.
5
Structural Elucidation and Relative Quantification of Fatty Acid Double Bond Positional Isomers in Biological Tissues Enabled by Gas-Phase Charge Inversion Ion/Ion Reactions.气相电荷反转离子/离子反应实现生物组织中脂肪酸双键位置异构体的结构解析和相对定量
Anal Sens. 2024 May;4(3). doi: 10.1002/anse.202300063. Epub 2023 Nov 13.
6
Sequencing of Phosphopeptides Using a Sequential Charge Inversion Ion/Ion Reaction and Electron Capture Dissociation Workflow.采用顺序电荷反转离子/离子反应和电子捕获解离工作流程对磷酸肽进行测序。
J Am Soc Mass Spectrom. 2024 Jul 3;35(7):1556-1566. doi: 10.1021/jasms.4c00147. Epub 2024 May 28.
7
Structural Elucidation of Ubiquitin via Gas-Phase Ion/Ion Cross-Linking Reactions Using Sodium-Cationized Reagents Coupled with Infrared Multiphoton Dissociation.通过使用与红外多光子解离耦联的钠离子化试剂进行气相离子/离子交联反应对泛素进行结构阐明。
Anal Chem. 2024 May 28;96(21):8518-8527. doi: 10.1021/acs.analchem.4c00442. Epub 2024 May 6.
8
Relative Quantification of Lipid Isomers in Imaging Mass Spectrometry Using Gas-Phase Charge Inversion Ion/Ion Reactions and Infrared Multiphoton Dissociation.利用气相电荷反转离子/离子反应和红外多光子解离对成像质谱中的脂质异构体进行相对定量。
Anal Chem. 2023 Dec 5;95(48):17766-17775. doi: 10.1021/acs.analchem.3c03804. Epub 2023 Nov 22.
9
Separation of Isobaric Lipids in Imaging Mass Spectrometry Using Gas-Phase Charge Inversion Ion/Ion Reactions.利用气相荷电反转离子/离子反应对成像质谱中同量异位脂质的分离。
J Am Soc Mass Spectrom. 2023 Sep 6;34(9):1868-1878. doi: 10.1021/jasms.3c00081. Epub 2023 Jun 5.
10
Recent Advances in Gas-phase Ion/Ion Chemistry for Lipid Analysis.脂质分析中气相离子/离子化学的最新进展
Trends Analyt Chem. 2023 Jan;158. doi: 10.1016/j.trac.2022.116852. Epub 2022 Nov 26.
本文引用的文献
1
A new approach for the study of gas-phase ion-ion reactions using electrospray ionization.利用电喷雾电离研究气相离子-离子反应的新方法。
J Am Soc Mass Spectrom. 1992 Oct;3(7):695-705. doi: 10.1016/1044-0305(92)87082-A.
2
Charge-state reduction with improved signal intensity of oligonucleotides in electrospray ionization mass spectrometry.电喷雾电离质谱中寡核苷酸的荷质比降低及其信号强度提高。
J Am Soc Mass Spectrom. 1996 Aug;7(8):697-706. doi: 10.1016/1044-0305(96)80516-2.
3
Gas-phase intramolecular protein crosslinking via ion/ion reactions: ubiquitin and a homobifunctional sulfo-NHS ester.气相分子内蛋白质交联通过离子/离子反应：泛素和同双功能磺基-NHS 酯。
J Am Soc Mass Spectrom. 2013 May;24(5):733-43. doi: 10.1007/s13361-013-0590-4. Epub 2013 Mar 5.
4
Gas-phase reactivity of carboxylic acid functional groups with carbodiimides.羧酸官能团与碳二亚胺的气相反应性。
J Am Soc Mass Spectrom. 2013 Jan;24(1):30-7. doi: 10.1007/s13361-012-0506-8. Epub 2012 Dec 4.
5
Peptide cross-linking at ambient surfaces by reactions of nanosprayed molecular cations.通过纳米喷雾分子阳离子反应在环境表面进行肽交联。
Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9417-21. doi: 10.1002/anie.201205044. Epub 2012 Aug 17.
6
Gas-phase conjugation to arginine residues in polypeptide ions via N-hydroxysuccinimide ester-based reagent ions.通过基于 N-羟基琥珀酰亚胺酯的试剂离子，在多肽离子中的精氨酸残基上进行气相偶联。
J Am Chem Soc. 2012 Jul 18;134(28):11412-4. doi: 10.1021/ja304778j. Epub 2012 Jul 6.
7
Covalent and non-covalent binding in the ion/ion charge inversion of peptide cations with benzene-disulfonic acid anions.肽阳离子与苯二磺酸阴离子的离子/离子电荷反转中的共价和非共价键合。
J Mass Spectrom. 2012 Jun;47(6):669-75. doi: 10.1002/jms.2968.
8
Dissociation Behavior of Tryptic and Intramolecular Disulfide-linked Peptide Ions Modified in the Gas Phase via Ion/Ion Reactions.通过离子/离子反应在气相中修饰的胰蛋白酶和分子内二硫键连接肽离子的解离行为
Int J Mass Spectrom. 2012 Feb 15;312:195-200. doi: 10.1016/j.ijms.2011.07.002.
9
Analysis of the acidic proteome with negative electron-transfer dissociation mass spectrometry.采用负离子电喷雾解析质谱法分析酸性蛋白质组。
Anal Chem. 2012 Mar 20;84(6):2875-82. doi: 10.1021/ac203430u. Epub 2012 Mar 1.
10
Cleavage of Multiple Disulfide Bonds in Insulin via Gold Cationization and Collision-induced Dissociation.通过金阳离子化和碰撞诱导解离对胰岛素中多个二硫键的裂解
Int J Mass Spectrom. 2011 Nov 1;308(1):133-136. doi: 10.1016/j.ijms.2011.08.013.
Zotero 插件