Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN 47907-2084, USA.
Chem Commun (Camb). 2013 Feb 1;49(10):947-65. doi: 10.1039/c2cc36577d. Epub 2012 Dec 20.
Gas-phase ion/ion reactions are emerging as useful and flexible means for the manipulation and characterization of peptide and protein biopolymers. Acid/base-like chemical reactions (i.e., proton transfer reactions) and reduction/oxidation (redox) reactions (i.e., electron transfer reactions) represent relatively mature classes of gas-phase chemical reactions. Even so, especially in regards to redox chemistry, the widespread utility of these two types of chemistries is undergoing rapid growth and development. Additionally, a relatively new class of gas-phase ion/ion transformations is emerging which involves the selective formation of functional-group-specific covalent bonds. This feature details our current work and perspective on the developments and current capabilities of these three areas of ion/ion chemistry with an eye towards possible future directions of the field.
气相离子/离子反应正成为一种有用且灵活的手段，可用于操纵和表征肽和蛋白质生物聚合物。酸/碱样化学反应（即质子转移反应）和还原/氧化（氧化还原）反应（即电子转移反应）代表了相对成熟的气相化学反应类别。即便如此，特别是在氧化还原化学方面，这两种类型的化学物质的广泛应用正在迅速发展和壮大。此外，一种新的气相离子/离子转化类型正在出现，涉及到特定官能团共价键的选择性形成。本文详细介绍了我们目前在离子/离子化学这三个领域的工作和观点，以及该领域未来可能的发展方向。
