López-González Miguel A, Abrante Antonio, López-Lorente Carmen, Gómez Antonio, Domínguez Emilio, Esteban Francisco
UGC Otorhinolaryngology, Virgen del Rocio University Hospital, C/Manuel Siurot s/n, 41013 Seville, Spain.
Int J Otolaryngol. 2012;2012:216592. doi: 10.1155/2012/216592. Epub 2012 Nov 6.
The acute-phase inflammatory response in the peripheral bloodstream can be an expression of transient cerebral ischaemia in idiopathic sudden deafness. For this, a neurological and otorhinolaryngological examination of each patient, performing tests on audiometry, and tympanometry, haemogram, and cranial magnetic resonance were performed. The acute-phase inflammatory response manifests as an increased neutrophil/lymphocyte ratio that is detected 48-72 hours after the appearance of sudden deafness. This study shows that there is an acute-phase response in the peripheral bloodstream with an increased neutrophil/lymphocyte ratio as an expression of an inflammatory process that can be caused by transient cerebral ischaemia in sudden deafness. In addition, the increased neutrophil/lymphocyte ratio can rule out a viral origin of sudden deafness, since a viral infection lowers the neutrophil count and increases the lymphocyte count, thus reducing the neutrophil/lymphocyte ratio. These findings aid in understanding the pathogenic mechanisms involved in sudden deafness and offer better treatment to the patient.
外周血流中的急性期炎症反应可能是特发性突发性聋中短暂性脑缺血的一种表现。为此，对每位患者进行了神经科和耳鼻喉科检查，包括听力测定、鼓室图、血常规和头颅磁共振检查。急性期炎症反应表现为中性粒细胞/淋巴细胞比值升高，在突发性聋出现后48 - 72小时可检测到。本研究表明，外周血流中存在急性期反应，中性粒细胞/淋巴细胞比值升高是炎症过程的一种表现，这可能由突发性聋中的短暂性脑缺血引起。此外，中性粒细胞/淋巴细胞比值升高可排除突发性聋的病毒起源，因为病毒感染会降低中性粒细胞计数并增加淋巴细胞计数，从而降低中性粒细胞/淋巴细胞比值。这些发现有助于理解突发性聋的致病机制，并为患者提供更好的治疗。
