Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, ul. Szamarzewskiego 84, Poznan, Poland.
Kardiol Pol. 2012;70(12):1237-42.
Adipocytes are hormonally active molecules modulating biochemical processes on-going in human organism. Visceral fat tissue is the source of many important substances, such as: adiponectin, TNF-α, resistin and many others. However, their role has not been fully elucidated.
The study included 85 patients with MetS, diagnosed according to the International Diabetes Federation (IDF) criteria from 2005, and 20 healthy volunteers as control subjects. In both groups, anthropological parameters (body mass index and waist circumference) and concentrations of adiponectin, soluble receptors for TNF-α and resistin were assessed. To measure adiponectin levels, radioimmunological and immunoenzymatic assays (sTNFR1, sTNFR2, and resistin) were employed.
Concentration of adiponectin was markedly lower in patients with MetS compared to the control group (10.892 ± 10.440 vs. 19.307 ± 19.370 μg/mL, p 〈 0.001). In patients with MetS, sTNFR1 and sTNFR2 concentrations were significantly elevated and resistin level was significantly higher compared to control subjects (25.865 ± 25.8 vs. 9.60 ± 9.915 ng/mL, p 〈 0.001). Negative correlations between adiponectin and the values of systolic blood pressure (SBP) (Rp = 0.2898, p 〈 0.001) and diastolic blood pressure (DBP) (Rp = 0.2724, p 〈 0.001) were observed. Positive correlations between sTNFR2 and SBP (Rp = 0.450, p 〈 0.001) and DBP (Rp = 0.4695, p 〈 0.001) values were found. Resistin levels correlated positively with SBP (Rp = 0.5154, p 〈 0.001) and DBP (Rp = 0.5613, p 〈 0.001) values. In multiple regression model, the association of SBP with resistin level was observed in 32% of studied patients.
脂肪细胞是调节人体生化过程的激素活性分子。内脏脂肪组织是许多重要物质的来源，如脂联素、TNF-α、抵抗素等。然而，它们的作用尚未完全阐明。
该研究纳入了 85 名根据国际糖尿病联合会（IDF）标准于 2005 年诊断为 MetS 的患者和 20 名健康志愿者作为对照组。在两组中，均评估了人体测量参数（体重指数和腰围）和脂联素、可溶性 TNF-α受体和抵抗素浓度。采用放射免疫和免疫酶联分析（sTNFR1、sTNFR2 和抵抗素）来测量脂联素水平。
与对照组相比，MetS 患者的脂联素浓度明显降低（10.892±10.440 与 19.307±19.370μg/mL，p〈0.001）。MetS 患者的 sTNFR1 和 sTNFR2 浓度显著升高，抵抗素水平显著高于对照组（25.865±25.8 与 9.60±9.915ng/mL，p〈0.001）。脂联素与收缩压（SBP）（Rp=0.2898，p〈0.001）和舒张压（DBP）（Rp=0.2724，p〈0.001）值呈负相关。sTNFR2 与 SBP（Rp=0.450，p〈0.001）和 DBP（Rp=0.4695，p〈0.001）值呈正相关。抵抗素水平与 SBP（Rp=0.5154，p〈0.001）和 DBP（Rp=0.5613，p〈0.001）值呈正相关。多元回归模型显示，32%的研究患者 SBP 与抵抗素水平相关。
