Masoumi Gholamreza, Pour Evaz Hidar, Sadeghpour Ali, Ziayeefard Mohsen, Alavi Mostapha, Anbardan Sanam Javid, Shirani Shahin
Assistant Professor, Department of Cardiology, Shahid Rajaee Hospital, Isfahan University of Medical Science, Isfahan, Iran.
J Res Med Sci. 2012 Feb;17(2):123-7.
On-pump coronary artery bypass graft (CABG) surgery impairs gas exchange in the early postoperative period. The main object on this study was evaluation of changes in arterial blood gas values in patients underwent on pump CABG surgery receiving different dose of intravenous nitroglycerin (NTG).
sixty-seven consecutive patients undergoing elective on-pump CABG randomly enrolled into three groups receiving NTG 50 μg/min (Group N1, n =67), 100 μg/min (Group N2, n = 67), and 150 μg/min (Group N3, n = 67). Arterial blood gas (ABG) tensions were evaluated just before induction of anesthesia, during anesthesia, at the end of warming up period, and 6 h after admission to the intensive care unit.
Pao2 and PH had the highest value during surgery in Group N1, Group N2, and Group N3. No significant difference was noted in mean values of Pao2 and PH during surgery between three groups (P > 0.05). There was no significant difference in HCO3 values in different time intervals among three groups (P > 0.05).
our results showed that infusing three different dosage of NTG (50, 100, and 150 μg/min) had no significant effect on ABG tensions in patients underwent on-pump CABG surgery.
体外循环冠状动脉旁路移植术（CABG）在术后早期会损害气体交换。本研究的主要目的是评估接受不同剂量静脉硝酸甘油（NTG）的体外循环CABG手术患者动脉血气值的变化。
67例连续接受择期体外循环CABG手术的患者被随机分为三组，分别接受50μg/min NTG（N1组，n = 67）、100μg/min NTG（N2组，n = 67）和150μg/min NTG（N3组，n = 67）。在麻醉诱导前、麻醉期间、复温期末以及入住重症监护病房6小时后评估动脉血气（ABG）张力。
N1组、N2组和N3组在手术期间Pao2和PH值最高。三组手术期间Pao2和PH的平均值无显著差异（P>0.05）。三组不同时间间隔的HCO3值无显著差异（P>0.05）。
我们的结果表明，输注三种不同剂量的NTG（50、100和150μg/min）对接受体外循环CABG手术的患者的ABG张力没有显著影响。
